Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337112451> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2337112451 endingPage "7" @default.
- W2337112451 startingPage "116" @default.
- W2337112451 abstract "The biochemical synthesis of human melanin is understood in some detail. However, little is known about melanin degradation and catabolism of melanin. We hypothesize that human skin contains enzymes that degrade melanin and these enzymes can be used to reduce skin color. To test this hypothesis, HaCaT keratinocytes and normal human keratinocytes in culture were pulse labeled for one hour with radiolabeled synthetic melanin. This melanin was synthesized in vitro using tyrosinase enzyme from mushrooms and using radiolabeled [14C]3,4-dihydroxyphenylalanine (DOPA) as a substrate. After the initial pulse labeling, samples of both the cells and media were taken at 2, 4, 6 and 18 hours. Over these time periods the counts remaining in the media and cell fraction were significantly decreased. This data suggests the need for new protein synthesis and the lysosome organelle function for the degradation. Melanin degrading extracts isolated from Aspergillus fumigatus and Saccharomyces cerevisiae were applied to human skin. These extracts cause significant reduction in UVB induced pigmentation. These extracts may be useful in developing new whitening products to even skin color and tone." @default.
- W2337112451 created "2016-06-24" @default.
- W2337112451 creator A5007604384 @default.
- W2337112451 creator A5007922379 @default.
- W2337112451 creator A5009930228 @default.
- W2337112451 creator A5036496847 @default.
- W2337112451 date "2004-03-24" @default.
- W2337112451 modified "2023-09-23" @default.
- W2337112451 title "Evidence and utility of melanin degrading enzymes." @default.
- W2337112451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15037924" @default.
- W2337112451 hasPublicationYear "2004" @default.
- W2337112451 type Work @default.
- W2337112451 sameAs 2337112451 @default.
- W2337112451 citedByCount "2" @default.
- W2337112451 countsByYear W23371124512012 @default.
- W2337112451 crossrefType "journal-article" @default.
- W2337112451 hasAuthorship W2337112451A5007604384 @default.
- W2337112451 hasAuthorship W2337112451A5007922379 @default.
- W2337112451 hasAuthorship W2337112451A5009930228 @default.
- W2337112451 hasAuthorship W2337112451A5036496847 @default.
- W2337112451 hasConcept C107538193 @default.
- W2337112451 hasConcept C118995209 @default.
- W2337112451 hasConcept C181199279 @default.
- W2337112451 hasConcept C185592680 @default.
- W2337112451 hasConcept C202751555 @default.
- W2337112451 hasConcept C2777459323 @default.
- W2337112451 hasConcept C2780216420 @default.
- W2337112451 hasConcept C54355233 @default.
- W2337112451 hasConcept C55493867 @default.
- W2337112451 hasConcept C86803240 @default.
- W2337112451 hasConcept C87554066 @default.
- W2337112451 hasConcept C96942376 @default.
- W2337112451 hasConceptScore W2337112451C107538193 @default.
- W2337112451 hasConceptScore W2337112451C118995209 @default.
- W2337112451 hasConceptScore W2337112451C181199279 @default.
- W2337112451 hasConceptScore W2337112451C185592680 @default.
- W2337112451 hasConceptScore W2337112451C202751555 @default.
- W2337112451 hasConceptScore W2337112451C2777459323 @default.
- W2337112451 hasConceptScore W2337112451C2780216420 @default.
- W2337112451 hasConceptScore W2337112451C54355233 @default.
- W2337112451 hasConceptScore W2337112451C55493867 @default.
- W2337112451 hasConceptScore W2337112451C86803240 @default.
- W2337112451 hasConceptScore W2337112451C87554066 @default.
- W2337112451 hasConceptScore W2337112451C96942376 @default.
- W2337112451 hasIssue "1" @default.
- W2337112451 hasLocation W23371124511 @default.
- W2337112451 hasOpenAccess W2337112451 @default.
- W2337112451 hasPrimaryLocation W23371124511 @default.
- W2337112451 hasRelatedWork W1913279048 @default.
- W2337112451 hasRelatedWork W1971016738 @default.
- W2337112451 hasRelatedWork W2041429253 @default.
- W2337112451 hasRelatedWork W2045445813 @default.
- W2337112451 hasRelatedWork W2337112451 @default.
- W2337112451 hasRelatedWork W2352764313 @default.
- W2337112451 hasRelatedWork W2359287693 @default.
- W2337112451 hasRelatedWork W2363480683 @default.
- W2337112451 hasRelatedWork W2388645848 @default.
- W2337112451 hasRelatedWork W2388986023 @default.
- W2337112451 hasVolume "55" @default.
- W2337112451 isParatext "false" @default.
- W2337112451 isRetracted "false" @default.
- W2337112451 magId "2337112451" @default.
- W2337112451 workType "article" @default.