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- W2337113109 abstract "Understanding the cellular internalization mechanism of nanoparticles is essential to study their biological fate. Especially, due to the anisotropic properties, rod-like nanoparticles have attracted growing interest for the enhanced internalization efficiency with respect to spherical nanoparticles. Here, to elucidate the effect of aspect ratio of rod-like nanoparticles on cellular uptake, tobacco mosaic virus (TMV), a typical rod-like bionanoparticle, is developed as a model. Nanorods with different aspect ratios can be obtained by ultrasound treatment and sucrose density gradient centrifugation. By incubating with epithelial and endothelial cells, we found that the rod-like bionanoparticles with various aspect ratios had different internalization pathways in different cell lines: microtubules transport in HeLa and clathrin-mediated uptake in HUVEC for TMV4 and TMV8; caveolae-mediated pathway and microtubules transport in HeLa and HUVEC for TMV17. Differently from most nanoparticles, for all the three TMV nano-rods with different aspect ratios, macropinocytosis takes no effect on the internalization in both cell types. This work provides a fundamental understanding of the influence of aspect ratio on cellular uptake decoupled from charge and material composition." @default.
- W2337113109 created "2016-06-24" @default.
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- W2337113109 date "2016-04-15" @default.
- W2337113109 modified "2023-10-11" @default.
- W2337113109 title "Size Dependent Cellular Uptake of Rod-like Bionanoparticles with Different Aspect Ratios" @default.
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- W2337113109 doi "https://doi.org/10.1038/srep24567" @default.
- W2337113109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4832221" @default.
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