Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337130094> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2337130094 endingPage "637" @default.
- W2337130094 startingPage "633" @default.
- W2337130094 abstract "[3H]Arachidonic acid is released after stimulation of rabbit neutrophils with fMet-Leu-Phe or platelet-activating factor (PAF). The release is rapid and dose-dependent, and is inhibited in phorbol 12-myristate 13-acetate (PMA)-treated rabbit neutrophils. The protein kinase C (PKC) inhibitor 1-(5-isoquinoline-sulphonyl)-2-methylpiperazine (H-7) prevents this inhibition. In addition, PMA increases arachidonic acid release in H-7-treated cells stimulated with fMet-Leu-Phe. [3H]Arachidonic acid release, but not the rise in the concentration of intracellular Ca2+, is inhibited in pertussis-toxin-treated neutrophils stimulated with PAF. The diacylglycerol kinase inhibitor R59022 increases the concentration of diacylglycerol and potentiates [3H]arachidonic acid release in neutrophils stimulated with fMet-Leu-Phe. This potentiation is not inhibited by H-7. These results suggest several points. (1) A rise in the intracellular concentration of free Ca2+ is not sufficient for arachidonic acid release in rabbit neutrophils stimulated by physiological stimuli. (2) A functional pertussis-toxin-sensitive guanine nucleotide regulatory protein and/or one or more of the changes produced by phospholipase C activation are necessary for arachidonic acid release produced by physiological stimuli. (3) Agents that stimulate PKC potentiate arachidonic acid release, and this potentiation is not inhibited by H-7. These agents produce their actions in part by direct membrane perturbation." @default.
- W2337130094 created "2016-06-24" @default.
- W2337130094 creator A5041965203 @default.
- W2337130094 creator A5057067211 @default.
- W2337130094 creator A5070665799 @default.
- W2337130094 date "1989-02-01" @default.
- W2337130094 modified "2023-10-18" @default.
- W2337130094 title "Arachidonic acid release in rabbit neutrophils" @default.
- W2337130094 cites W1029812605 @default.
- W2337130094 cites W1502032494 @default.
- W2337130094 cites W1533165549 @default.
- W2337130094 cites W1573558348 @default.
- W2337130094 cites W16075687 @default.
- W2337130094 cites W1911780819 @default.
- W2337130094 cites W1978765961 @default.
- W2337130094 cites W1979065558 @default.
- W2337130094 cites W1983649160 @default.
- W2337130094 cites W1986849775 @default.
- W2337130094 cites W1996829988 @default.
- W2337130094 cites W2001586236 @default.
- W2337130094 cites W2009405144 @default.
- W2337130094 cites W2015072125 @default.
- W2337130094 cites W2015547530 @default.
- W2337130094 cites W2018717407 @default.
- W2337130094 cites W2052295727 @default.
- W2337130094 cites W2062986756 @default.
- W2337130094 cites W2154657571 @default.
- W2337130094 cites W2168067948 @default.
- W2337130094 cites W2340417218 @default.
- W2337130094 cites W2409060664 @default.
- W2337130094 cites W2466776862 @default.
- W2337130094 doi "https://doi.org/10.1042/bj2570633" @default.
- W2337130094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1135634" @default.
- W2337130094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2494986" @default.
- W2337130094 hasPublicationYear "1989" @default.
- W2337130094 type Work @default.
- W2337130094 sameAs 2337130094 @default.
- W2337130094 citedByCount "46" @default.
- W2337130094 countsByYear W23371300942019 @default.
- W2337130094 countsByYear W23371300942020 @default.
- W2337130094 crossrefType "journal-article" @default.
- W2337130094 hasAuthorship W2337130094A5041965203 @default.
- W2337130094 hasAuthorship W2337130094A5057067211 @default.
- W2337130094 hasAuthorship W2337130094A5070665799 @default.
- W2337130094 hasBestOaLocation W23371300942 @default.
- W2337130094 hasConcept C170493617 @default.
- W2337130094 hasConcept C181199279 @default.
- W2337130094 hasConcept C184235292 @default.
- W2337130094 hasConcept C185592680 @default.
- W2337130094 hasConcept C195794163 @default.
- W2337130094 hasConcept C2776551241 @default.
- W2337130094 hasConcept C2778078955 @default.
- W2337130094 hasConcept C2778597717 @default.
- W2337130094 hasConcept C2780043322 @default.
- W2337130094 hasConcept C36020004 @default.
- W2337130094 hasConcept C49773422 @default.
- W2337130094 hasConcept C55493867 @default.
- W2337130094 hasConcept C79879829 @default.
- W2337130094 hasConcept C80631254 @default.
- W2337130094 hasConcept C86803240 @default.
- W2337130094 hasConceptScore W2337130094C170493617 @default.
- W2337130094 hasConceptScore W2337130094C181199279 @default.
- W2337130094 hasConceptScore W2337130094C184235292 @default.
- W2337130094 hasConceptScore W2337130094C185592680 @default.
- W2337130094 hasConceptScore W2337130094C195794163 @default.
- W2337130094 hasConceptScore W2337130094C2776551241 @default.
- W2337130094 hasConceptScore W2337130094C2778078955 @default.
- W2337130094 hasConceptScore W2337130094C2778597717 @default.
- W2337130094 hasConceptScore W2337130094C2780043322 @default.
- W2337130094 hasConceptScore W2337130094C36020004 @default.
- W2337130094 hasConceptScore W2337130094C49773422 @default.
- W2337130094 hasConceptScore W2337130094C55493867 @default.
- W2337130094 hasConceptScore W2337130094C79879829 @default.
- W2337130094 hasConceptScore W2337130094C80631254 @default.
- W2337130094 hasConceptScore W2337130094C86803240 @default.
- W2337130094 hasIssue "3" @default.
- W2337130094 hasLocation W23371300941 @default.
- W2337130094 hasLocation W23371300942 @default.
- W2337130094 hasLocation W23371300943 @default.
- W2337130094 hasLocation W23371300944 @default.
- W2337130094 hasOpenAccess W2337130094 @default.
- W2337130094 hasPrimaryLocation W23371300941 @default.
- W2337130094 hasRelatedWork W1970177217 @default.
- W2337130094 hasRelatedWork W1972664132 @default.
- W2337130094 hasRelatedWork W1992084443 @default.
- W2337130094 hasRelatedWork W2002676856 @default.
- W2337130094 hasRelatedWork W2026140658 @default.
- W2337130094 hasRelatedWork W2038833808 @default.
- W2337130094 hasRelatedWork W2070322955 @default.
- W2337130094 hasRelatedWork W2205110175 @default.
- W2337130094 hasRelatedWork W2337130094 @default.
- W2337130094 hasRelatedWork W1980315358 @default.
- W2337130094 hasVolume "257" @default.
- W2337130094 isParatext "false" @default.
- W2337130094 isRetracted "false" @default.
- W2337130094 magId "2337130094" @default.
- W2337130094 workType "article" @default.