FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337130347> ?p ?o ?g. }

• W2337130347 abstract "Background Optimal management of pleurodesis for malignant pleural effusion (MPE) has not been defined either in terms of optimal analgesia or chest tube size. Non-steroidal anti-inflammatory drugs (NSAID) are highly effective analgesics, but are avoided in pleurodesis as they may reduce pleurodesis efficacy. Smaller ( Methods A 2 × 2 factorial, phase 3 randomised controlled trial in 320 patients with MPE undergoing pleurodesis. Patients were randomised to opiate/NSAID and 24 French drain/12 French drain. Co-primary outcomes were; pain while tube in situ , measured on 100 mm visual analogue scale (VAS) over 5 days (superiority comparison) and pleurodesis efficacy at 3 months (non-inferiority comparison, margin of non-inferiority 15%). Secondary outcomes included use of rescue analgesia, pleurodesis success to 6 months, adverse events and mortality. Results 320 patients were randomised (63% male, mean age 71.8 years), with similar baseline characteristics. Mean VAS scores in opiate and NSAID groups were similar (adjusted mean difference, -1.5 mm (95% confidence interval [CI], -5.0 to 2.0; p = 0.40). Patients receiving NSAID required more rescue analgesia (38% vs. 26%). Pleurodesis failure occurred in 33/144 (23%) NSAID patients compared with 30/150 (20%) of participants receiving opiate, meeting criteria (15%) for non-inferiority (difference 3%; (90% CI -5% to 10%)). Smaller chest tubes were modestly less painful than larger tubes (adjusted mean difference, -6.0 mm (95% CI, -11.7 to -0.2; p = 0.04)) and were associated with a higher pleurodesis failure rate which failed to meet non-inferiority criteria (pleurodesis failure 15/50 (30%) and 12/50 (24%) respectively, difference 6% (90% CI, -9% to 20%)). Adverse events did not differ between analgesic groups, but complications during insertion occurred more commonly with smaller drains (adjusted odds ratio, 1.91; 95% CI 0.71 to 5.13, p = 0.20). Conclusion NSAID and opiate analgesia were not significantly different in treatment of post-pleurodesis pain and neither was associated with impaired efficacy of pleurodesis. Smaller chest tubes were associated with less pain, but may be associated with reduced pleurodesis success compared with larger tubes. These results challenge current guidelines for pleurodesis of MPE, which advocate avoidance of NSAID and use of small chest tubes." @default.
• W2337130347 created "2016-06-24" @default.
• W2337130347 creator A5001955777 @default.
• W2337130347 creator A5002060238 @default.
• W2337130347 creator A5004569367 @default.
• W2337130347 creator A5006736272 @default.
• W2337130347 creator A5012867531 @default.
• W2337130347 creator A5013010635 @default.
• W2337130347 creator A5013586484 @default.
• W2337130347 creator A5017415418 @default.
• W2337130347 creator A5019423117 @default.
• W2337130347 creator A5021678788 @default.
• W2337130347 creator A5026183673 @default.
• W2337130347 creator A5041817017 @default.
• W2337130347 creator A5042964530 @default.
• W2337130347 creator A5046014607 @default.
• W2337130347 creator A5047810606 @default.
• W2337130347 creator A5048009571 @default.
• W2337130347 creator A5049329206 @default.
• W2337130347 creator A5050162178 @default.
• W2337130347 creator A5050641759 @default.
• W2337130347 creator A5050747540 @default.
• W2337130347 creator A5050973647 @default.
• W2337130347 creator A5059272486 @default.
• W2337130347 creator A5063094052 @default.
• W2337130347 creator A5066390499 @default.
• W2337130347 creator A5068383005 @default.
• W2337130347 creator A5080049157 @default.
• W2337130347 creator A5080570868 @default.
• W2337130347 creator A5081633297 @default.
• W2337130347 creator A5085607695 @default.
• W2337130347 creator A5087099593 @default.
• W2337130347 creator A5088323334 @default.
• W2337130347 creator A5089304233 @default.
• W2337130347 date "2015-11-12" @default.
• W2337130347 modified "2023-09-26" @default.
• W2337130347 title "S20 Primary Result of the 1st Therapeutic Interventions in Malignant Effusion (TIME1) Trial: A 2 × 2 factorial, randomised trial of chest tube size and analgesic strategy for pleurodesis in malignant pleural effusion" @default.
• W2337130347 doi "https://doi.org/10.1136/thoraxjnl-2015-207770.26" @default.
• W2337130347 hasPublicationYear "2015" @default.
• W2337130347 type Work @default.
• W2337130347 sameAs 2337130347 @default.
• W2337130347 citedByCount "1" @default.
• W2337130347 countsByYear W23371303472021 @default.
• W2337130347 crossrefType "journal-article" @default.
• W2337130347 hasAuthorship W2337130347A5001955777 @default.
• W2337130347 hasAuthorship W2337130347A5002060238 @default.
• W2337130347 hasAuthorship W2337130347A5004569367 @default.
• W2337130347 hasAuthorship W2337130347A5006736272 @default.
• W2337130347 hasAuthorship W2337130347A5012867531 @default.
• W2337130347 hasAuthorship W2337130347A5013010635 @default.
• W2337130347 hasAuthorship W2337130347A5013586484 @default.
• W2337130347 hasAuthorship W2337130347A5017415418 @default.
• W2337130347 hasAuthorship W2337130347A5019423117 @default.
• W2337130347 hasAuthorship W2337130347A5021678788 @default.
• W2337130347 hasAuthorship W2337130347A5026183673 @default.
• W2337130347 hasAuthorship W2337130347A5041817017 @default.
• W2337130347 hasAuthorship W2337130347A5042964530 @default.
• W2337130347 hasAuthorship W2337130347A5046014607 @default.
• W2337130347 hasAuthorship W2337130347A5047810606 @default.
• W2337130347 hasAuthorship W2337130347A5048009571 @default.
• W2337130347 hasAuthorship W2337130347A5049329206 @default.
• W2337130347 hasAuthorship W2337130347A5050162178 @default.
• W2337130347 hasAuthorship W2337130347A5050641759 @default.
• W2337130347 hasAuthorship W2337130347A5050747540 @default.
• W2337130347 hasAuthorship W2337130347A5050973647 @default.
• W2337130347 hasAuthorship W2337130347A5059272486 @default.
• W2337130347 hasAuthorship W2337130347A5063094052 @default.
• W2337130347 hasAuthorship W2337130347A5066390499 @default.
• W2337130347 hasAuthorship W2337130347A5068383005 @default.
• W2337130347 hasAuthorship W2337130347A5080049157 @default.
• W2337130347 hasAuthorship W2337130347A5080570868 @default.
• W2337130347 hasAuthorship W2337130347A5081633297 @default.
• W2337130347 hasAuthorship W2337130347A5085607695 @default.
• W2337130347 hasAuthorship W2337130347A5087099593 @default.
• W2337130347 hasAuthorship W2337130347A5088323334 @default.
• W2337130347 hasAuthorship W2337130347A5089304233 @default.
• W2337130347 hasBestOaLocation W23371303471 @default.
• W2337130347 hasConcept C126322002 @default.
• W2337130347 hasConcept C141071460 @default.
• W2337130347 hasConcept C14184104 @default.
• W2337130347 hasConcept C168563851 @default.
• W2337130347 hasConcept C197934379 @default.
• W2337130347 hasConcept C2776232967 @default.
• W2337130347 hasConcept C2776979038 @default.
• W2337130347 hasConcept C2777063151 @default.
• W2337130347 hasConcept C2778329176 @default.
• W2337130347 hasConcept C2779634585 @default.
• W2337130347 hasConcept C2780820201 @default.
• W2337130347 hasConcept C42219234 @default.
• W2337130347 hasConcept C44249647 @default.
• W2337130347 hasConcept C71924100 @default.
• W2337130347 hasConceptScore W2337130347C126322002 @default.
• W2337130347 hasConceptScore W2337130347C141071460 @default.
• W2337130347 hasConceptScore W2337130347C14184104 @default.
• W2337130347 hasConceptScore W2337130347C168563851 @default.
• W2337130347 hasConceptScore W2337130347C197934379 @default.
• W2337130347 hasConceptScore W2337130347C2776232967 @default.
• W2337130347 hasConceptScore W2337130347C2776979038 @default.
• W2337130347 hasConceptScore W2337130347C2777063151 @default.
• W2337130347 hasConceptScore W2337130347C2778329176 @default.

• next