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- W2337134345 abstract "Introduction: Gall bladder cancer (GBC) is predominantly a disease of the Indian subcontinent especially in the Ganges belt of Northern India with an age adjusted incidence of 9–14 per 100,000 women annually. World literature on GBC is sparse and most has been extrapolated from studies where cholangiocarcinoma is combined with GBC. Methods: Retrospective analysis of a prospectively maintained database from Jan 2010–Aug 2015 was performed. Peri-operative and long term outcomes were analyzed. Results: 515 patients underwent surgery for suspected GBC of which 400 had a histology proven malignancy. Median age of presentation was 51 years. Female: Male ratio was 2.3: 1. 81 patients were deemed inoperable.160 patients underwent a revision surgery for a diagnosis of incidental GBC whereas radical cholecystectomy was performed in 152 patients and scar excision in 7 patients. 14 patients required extrahepatic bile duct excision and 9 patients underwent additional organ resection for negative margins. 39 patients underwent preoperative biliary drainage. 91 patients received neoadjuvant chemotherapy and 21 patients received neoadjuvant chemoradiation. Average blood loss was 550 ml and median hospital stay was 3 days. Morbidity rate was 7.5% (n = 30) and mortality 1% (n = 4). Adjuvant chemotherapy was given to 210 patients (pT3, T4 and Node positive disease). 15 patients also received adjuvant radiation for microscopic positive margin. At a median follow up of 12 months the estimated 3 year overall survival was 79.4% and disease free survival was 72.5%. Conclusion: In patients with GBC surgical resection remains the treatment of choice with favorable long term outcomes." @default.
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- W2337134345 date "2016-04-01" @default.
- W2337134345 modified "2023-09-27" @default.
- W2337134345 title "Outcomes following surgical resection of 515 patients with gall bladder cancer: Indian experience" @default.
- W2337134345 doi "https://doi.org/10.1016/j.hpb.2016.02.127" @default.
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