Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337138889> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2337138889 endingPage "H2360" @default.
- W2337138889 startingPage "H2353" @default.
- W2337138889 abstract "Endothelin-1 (ET-1) is a vasoconstrictor and proinflammatory peptide, but its role in the vascular response to sepsis is unknown. After intraperitoneal injection of male Wistar rats (300 g) with 20 mg/kg of Salmonella enteritidis lipopolysaccharide (LPS), the expression of ET-1 mRNA was significantly increased in pulmonary artery and aorta within 1 h and arterial ET-1 concentration was elevated. Despite this increase in ET-1 production, there was no difference in baseline systemic or pulmonary arterial pressures between control and endotoxin-treated rats, and, furthermore, combined ETA/ETB receptor antagonism using bosentan produced reductions in systemic and pulmonary arterial pressures that were not greater than the modest fall seen in controls. However, bosentan completely antagonized the hemodynamic effects of exogenous ET-1 in controls but only weakly antagonized its effects in LPS animals. After LPS the initial (ETB-mediated) systemic hypotensive responses to ET-1 were attenuated, but the subsequent systemic pressor responses were not. By contrast, the increases in pulmonary arterial pressure in response to ET-1 and the ETB receptor agonist sarafotoxin S6c were significantly reduced in LPS animals. Vascular ET-1 mRNA expression and arterial ET-1 concentration are elevated after LPS treatment in rats, but the functional activity of ET-1 cannot be exposed by combined ETA/ETB receptor antagonism, possibly because of an alteration in the functional status of ET receptors." @default.
- W2337138889 created "2016-06-24" @default.
- W2337138889 creator A5002020342 @default.
- W2337138889 creator A5042336210 @default.
- W2337138889 creator A5068591649 @default.
- W2337138889 creator A5079367105 @default.
- W2337138889 date "1997-05-01" @default.
- W2337138889 modified "2023-09-25" @default.
- W2337138889 title "Endothelin-1 in rat endotoxemia: mRNA expression and vasoreactivity in pulmonary and systemic circulations" @default.
- W2337138889 doi "https://doi.org/10.1152/ajpheart.1997.272.5.h2353" @default.
- W2337138889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9176305" @default.
- W2337138889 hasPublicationYear "1997" @default.
- W2337138889 type Work @default.
- W2337138889 sameAs 2337138889 @default.
- W2337138889 citedByCount "7" @default.
- W2337138889 countsByYear W23371388892016 @default.
- W2337138889 crossrefType "journal-article" @default.
- W2337138889 hasAuthorship W2337138889A5002020342 @default.
- W2337138889 hasAuthorship W2337138889A5042336210 @default.
- W2337138889 hasAuthorship W2337138889A5068591649 @default.
- W2337138889 hasAuthorship W2337138889A5079367105 @default.
- W2337138889 hasConcept C126322002 @default.
- W2337138889 hasConcept C134018914 @default.
- W2337138889 hasConcept C144980905 @default.
- W2337138889 hasConcept C149601957 @default.
- W2337138889 hasConcept C170493617 @default.
- W2337138889 hasConcept C2776345702 @default.
- W2337138889 hasConcept C2778384902 @default.
- W2337138889 hasConcept C2778754761 @default.
- W2337138889 hasConcept C2778938600 @default.
- W2337138889 hasConcept C2779961880 @default.
- W2337138889 hasConcept C2780940725 @default.
- W2337138889 hasConcept C2781109936 @default.
- W2337138889 hasConcept C2909649922 @default.
- W2337138889 hasConcept C71924100 @default.
- W2337138889 hasConceptScore W2337138889C126322002 @default.
- W2337138889 hasConceptScore W2337138889C134018914 @default.
- W2337138889 hasConceptScore W2337138889C144980905 @default.
- W2337138889 hasConceptScore W2337138889C149601957 @default.
- W2337138889 hasConceptScore W2337138889C170493617 @default.
- W2337138889 hasConceptScore W2337138889C2776345702 @default.
- W2337138889 hasConceptScore W2337138889C2778384902 @default.
- W2337138889 hasConceptScore W2337138889C2778754761 @default.
- W2337138889 hasConceptScore W2337138889C2778938600 @default.
- W2337138889 hasConceptScore W2337138889C2779961880 @default.
- W2337138889 hasConceptScore W2337138889C2780940725 @default.
- W2337138889 hasConceptScore W2337138889C2781109936 @default.
- W2337138889 hasConceptScore W2337138889C2909649922 @default.
- W2337138889 hasConceptScore W2337138889C71924100 @default.
- W2337138889 hasIssue "5" @default.
- W2337138889 hasLocation W23371388891 @default.
- W2337138889 hasLocation W23371388892 @default.
- W2337138889 hasOpenAccess W2337138889 @default.
- W2337138889 hasPrimaryLocation W23371388891 @default.
- W2337138889 hasRelatedWork W1987955998 @default.
- W2337138889 hasRelatedWork W1995823730 @default.
- W2337138889 hasRelatedWork W2013620060 @default.
- W2337138889 hasRelatedWork W2017344644 @default.
- W2337138889 hasRelatedWork W2083609063 @default.
- W2337138889 hasRelatedWork W2141307244 @default.
- W2337138889 hasRelatedWork W2160355439 @default.
- W2337138889 hasRelatedWork W2415263005 @default.
- W2337138889 hasRelatedWork W2416973539 @default.
- W2337138889 hasRelatedWork W2495573191 @default.
- W2337138889 hasVolume "272" @default.
- W2337138889 isParatext "false" @default.
- W2337138889 isRetracted "false" @default.
- W2337138889 magId "2337138889" @default.
- W2337138889 workType "article" @default.