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• W2337150420 abstract "The challenge in drug targeting is not only the targeting of drug to a specific site but also retaining it for the desired duration to elicit pharmacological action. For a nanosystem administered intravenously, the first and foremost barrier is that of the vascular endothelium and the basement membrane. Also, plasma proteins have the ability to affect the biodistribution of drug carrier systems introduced in the blood stream. The in vivo biodistribution and opsonization of nanosystems in blood circulation is governed by their size and surface characteristics. For the nanosystem to remain in blood circulation for a long time, the major problem is to avoid its opsonization and subsequent uptake by the phagocytic cells. The tight endothelial cells in brain constitute the blood brain barrier (BBB), which restricts the entry of most drugs and delivery systems. However vascular endothelium is not uniform throughout. Another barrier is that of the extracellular matrix, which should be crossed to access the target cells in a tissue. If the whole tissue constitutes a target then the uniform distribution of drug throughout the tissue is another problem." @default.
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• W2337150420 date "2011-01-01" @default.
• W2337150420 modified "2023-09-26" @default.
• W2337150420 title "DRUG TARGETING TO BRAIN : A REVIEW" @default.
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