FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W233715507> ?p ?o ?g. }

• W233715507 endingPage "94" @default.
• W233715507 startingPage "273" @default.
• W233715507 abstract "Previous reports from the Tuberculosis Chemotherapy Centre, Madras, have described a comparison of four regimens (three of isoniazid alone and one of isoniazid plus PAS) in the treatment of pulmonary tuberculosis and an investigation of the serum isoniazid levels in the patients concerned. The present report studies the emergence of isoniazid-resistant organisms in these patients during treatment. All patients with an unsatisfactory response to treatment yielded resistant cultures, showing that the isoniazid dosage was never too low to inhibit sensitive organisms. From the degree of resistance of the first resistant cultures and of the six-month cultures from the patients treated with isoniazid alone it was concluded that resistance emerged in two stages. In the first stage, very earlyin treatment, highly resistant mutant bacilli grew freely whatever the isoniazid dosage, but mutants of lower resistance were prevented from growing to an extent dependent on the peak isoniazid concentration in the serum. Consequently, when the isoniazid dosage was increased the proportion of patients with resistant organisms decreased, since fewer low-resistance strains were able to develop. In the second stage, organisms with relatively low resistance continued to multiply, though still partially inhibited by isoniazid, and became more resistant, particularly in slow inactivators. The first-stage events determined the results of treatment since, once resistance had emerged, its extent was unrelated to the patient's eventual progress. These findings emphasize the importance of early intensive chemotherapy and adjustment of the isoniazid dosage according to peak serum concentrations rather than concentrations measured three or six hours after the dose. Concomitant administration of PAS prevented emergence of isoniazid resistance in many patients and in others delayed its emergence and reduced its degree, possibly because growth in the second stage was slow." @default.
• W233715507 created "2016-06-24" @default.
• W233715507 creator A5003872258 @default.
• W233715507 creator A5019940804 @default.
• W233715507 creator A5035268079 @default.
• W233715507 creator A5060352437 @default.
• W233715507 creator A5072362660 @default.
• W233715507 creator A5083922394 @default.
• W233715507 creator A5087155667 @default.
• W233715507 date "1964-01-01" @default.
• W233715507 modified "2023-09-26" @default.
• W233715507 title "THE EMERGENCE OF ISONIAZID-RESISTANT CULTURES IN PATIENTS WITH PULMONARY TUBERCULOSIS DURING TREATMENT WITH ISONIAZID ALONE OR ISONIAZID PLUS PAS." @default.
• W233715507 cites W1591653472 @default.
• W233715507 cites W1663949815 @default.
• W233715507 cites W1969095767 @default.
• W233715507 cites W2054950457 @default.
• W233715507 cites W214166965 @default.
• W233715507 cites W2175174075 @default.
• W233715507 cites W2338904488 @default.
• W233715507 cites W2409824929 @default.
• W233715507 cites W2410888519 @default.
• W233715507 cites W2421886710 @default.
• W233715507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2555166" @default.
• W233715507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14253244" @default.
• W233715507 hasPublicationYear "1964" @default.
• W233715507 type Work @default.
• W233715507 sameAs 233715507 @default.
• W233715507 citedByCount "26" @default.
• W233715507 countsByYear W2337155072013 @default.
• W233715507 countsByYear W2337155072015 @default.
• W233715507 countsByYear W2337155072016 @default.
• W233715507 countsByYear W2337155072017 @default.
• W233715507 countsByYear W2337155072018 @default.
• W233715507 countsByYear W2337155072022 @default.
• W233715507 countsByYear W2337155072023 @default.
• W233715507 crossrefType "journal-article" @default.
• W233715507 hasAuthorship W233715507A5003872258 @default.
• W233715507 hasAuthorship W233715507A5019940804 @default.
• W233715507 hasAuthorship W233715507A5035268079 @default.
• W233715507 hasAuthorship W233715507A5060352437 @default.
• W233715507 hasAuthorship W233715507A5072362660 @default.
• W233715507 hasAuthorship W233715507A5083922394 @default.
• W233715507 hasAuthorship W233715507A5087155667 @default.
• W233715507 hasConcept C114851261 @default.
• W233715507 hasConcept C126322002 @default.
• W233715507 hasConcept C142724271 @default.
• W233715507 hasConcept C2776967927 @default.
• W233715507 hasConcept C2781069245 @default.
• W233715507 hasConcept C71924100 @default.
• W233715507 hasConcept C86803240 @default.
• W233715507 hasConcept C89423630 @default.
• W233715507 hasConcept C98274493 @default.
• W233715507 hasConceptScore W233715507C114851261 @default.
• W233715507 hasConceptScore W233715507C126322002 @default.
• W233715507 hasConceptScore W233715507C142724271 @default.
• W233715507 hasConceptScore W233715507C2776967927 @default.
• W233715507 hasConceptScore W233715507C2781069245 @default.
• W233715507 hasConceptScore W233715507C71924100 @default.
• W233715507 hasConceptScore W233715507C86803240 @default.
• W233715507 hasConceptScore W233715507C89423630 @default.
• W233715507 hasConceptScore W233715507C98274493 @default.
• W233715507 hasLocation W2337155071 @default.
• W233715507 hasOpenAccess W233715507 @default.
• W233715507 hasPrimaryLocation W2337155071 @default.
• W233715507 hasRelatedWork W1591653472 @default.
• W233715507 hasRelatedWork W1599232796 @default.
• W233715507 hasRelatedWork W1663949815 @default.
• W233715507 hasRelatedWork W1963625941 @default.
• W233715507 hasRelatedWork W1978391059 @default.
• W233715507 hasRelatedWork W2000611000 @default.
• W233715507 hasRelatedWork W2006941455 @default.
• W233715507 hasRelatedWork W2033228816 @default.
• W233715507 hasRelatedWork W2040973437 @default.
• W233715507 hasRelatedWork W2062198515 @default.
• W233715507 hasRelatedWork W2086082886 @default.
• W233715507 hasRelatedWork W2116200710 @default.
• W233715507 hasRelatedWork W2117466548 @default.
• W233715507 hasRelatedWork W2120873364 @default.
• W233715507 hasRelatedWork W2124600282 @default.
• W233715507 hasRelatedWork W2156267968 @default.
• W233715507 hasRelatedWork W2274640761 @default.
• W233715507 hasRelatedWork W2408906035 @default.
• W233715507 hasRelatedWork W2411336099 @default.
• W233715507 hasRelatedWork W2400958904 @default.
• W233715507 hasVolume "31" @default.
• W233715507 isParatext "false" @default.
• W233715507 isRetracted "false" @default.
• W233715507 magId "233715507" @default.
• W233715507 workType "article" @default.