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• W2337163684 abstract "Although cell cycle control is an ancient, conserved, and essential process, some core animal and fungal cell cycle regulators share no more sequence identity than non-homologous proteins. Here, we show that evolution along the fungal lineage was punctuated by the early acquisition and entrainment of the SBF transcription factor through horizontal gene transfer. Cell cycle evolution in the fungal ancestor then proceeded through a hybrid network containing both SBF and its ancestral animal counterpart E2F, which is still maintained in many basal fungi. We hypothesize that a virally-derived SBF may have initially hijacked cell cycle control by activating transcription via the cis-regulatory elements targeted by the ancestral cell cycle regulator E2F, much like extant viral oncogenes. Consistent with this hypothesis, we show that SBF can regulate promoters with E2F binding sites in budding yeast." @default.
• W2337163684 created "2016-06-24" @default.
• W2337163684 creator A5011166807 @default.
• W2337163684 creator A5050898320 @default.
• W2337163684 creator A5066910593 @default.
• W2337163684 creator A5068790564 @default.
• W2337163684 creator A5082030263 @default.
• W2337163684 date "2016-05-10" @default.
• W2337163684 modified "2023-10-14" @default.
• W2337163684 title "Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi" @default.
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