Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337209409> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2337209409 endingPage "116" @default.
- W2337209409 startingPage "116" @default.
- W2337209409 abstract "Background and aim of workLiver fibrosis is a major health problem associated with high morbidity and mortality, particularly in Egypt. It is mainly regulated by hepatic stellate cells, which acquire a fibrogenic character in response to oxidant stress and inflammatory cytokines. We tried to test the efficacy of Saussurea lappa (Sl) root extract on the reversion of the already established liver fibrosis as this extract was reported to have anti-inflammatory and antioxidant activities.Materials and methodsA total of 24 albino rats were divided into four groups: negative control group, carbon tetrachloride (CCl 4 ) fibrosis model group, spontaneous resolution group, CCl 4 followed by Sl root extract group. In all rats, serum alanine transaminase, aspartate transaminase, liver malonaldehyde and liver reduced glutathione were measured. Histopathological assessment were carried out through haematoxylin and eosin (H&E), sirius red staining and α-smooth muscle actin immunohistochemical staining with evaluation of the fibrosis grade and percentage of the area occupied by collagen fibres.ResultsAdministration of Sl root extract for 4 weeks, after 8 weeks of CCl 4 injection, caused a significant decrease in CCl 4 -induced rise in plasma levels of alanine transaminase and aspartate transaminase, liver malonaldehyde and the percentage of collagen area and an increase in liver glutathione with almost preserved liver architecture, less inflammatory infiltration, less collagen deposition, fewer thinner septa, less bridging fibrosis and less positive reaction for α-smooth muscle actin as compared with the spontaneous resolution group.ConclusionThese data indicate that Sl root extract can accelerate matrix degradation and reversion from liver fibrosis induced by CCl 4 in rats. This might be through antioxidant, anti-inflammatory activities and through inhibition of the activated hepatic stellate cells or probably inducing their apoptosis." @default.
- W2337209409 created "2016-06-24" @default.
- W2337209409 creator A5048884535 @default.
- W2337209409 creator A5064163988 @default.
- W2337209409 creator A5065711956 @default.
- W2337209409 creator A5091672316 @default.
- W2337209409 date "2015-01-01" @default.
- W2337209409 modified "2023-09-26" @default.
- W2337209409 title "Saussurea lappa root extract accelerates the reversion of liver fibrosis induced by carbon tetrachloride in rats" @default.
- W2337209409 cites W2017387745 @default.
- W2337209409 cites W2035085937 @default.
- W2337209409 cites W2419640396 @default.
- W2337209409 cites W2495566817 @default.
- W2337209409 cites W4255166647 @default.
- W2337209409 cites W612978549 @default.
- W2337209409 doi "https://doi.org/10.4103/1110-208x.180324" @default.
- W2337209409 hasPublicationYear "2015" @default.
- W2337209409 type Work @default.
- W2337209409 sameAs 2337209409 @default.
- W2337209409 citedByCount "2" @default.
- W2337209409 countsByYear W23372094092021 @default.
- W2337209409 countsByYear W23372094092022 @default.
- W2337209409 crossrefType "journal-article" @default.
- W2337209409 hasAuthorship W2337209409A5048884535 @default.
- W2337209409 hasAuthorship W2337209409A5064163988 @default.
- W2337209409 hasAuthorship W2337209409A5065711956 @default.
- W2337209409 hasAuthorship W2337209409A5091672316 @default.
- W2337209409 hasConcept C126322002 @default.
- W2337209409 hasConcept C134018914 @default.
- W2337209409 hasConcept C142724271 @default.
- W2337209409 hasConcept C160160445 @default.
- W2337209409 hasConcept C178790620 @default.
- W2337209409 hasConcept C181199279 @default.
- W2337209409 hasConcept C185592680 @default.
- W2337209409 hasConcept C2776877979 @default.
- W2337209409 hasConcept C2777359374 @default.
- W2337209409 hasConcept C2778606649 @default.
- W2337209409 hasConcept C2779679107 @default.
- W2337209409 hasConcept C2779770810 @default.
- W2337209409 hasConcept C2780559512 @default.
- W2337209409 hasConcept C538909803 @default.
- W2337209409 hasConcept C55493867 @default.
- W2337209409 hasConcept C71924100 @default.
- W2337209409 hasConceptScore W2337209409C126322002 @default.
- W2337209409 hasConceptScore W2337209409C134018914 @default.
- W2337209409 hasConceptScore W2337209409C142724271 @default.
- W2337209409 hasConceptScore W2337209409C160160445 @default.
- W2337209409 hasConceptScore W2337209409C178790620 @default.
- W2337209409 hasConceptScore W2337209409C181199279 @default.
- W2337209409 hasConceptScore W2337209409C185592680 @default.
- W2337209409 hasConceptScore W2337209409C2776877979 @default.
- W2337209409 hasConceptScore W2337209409C2777359374 @default.
- W2337209409 hasConceptScore W2337209409C2778606649 @default.
- W2337209409 hasConceptScore W2337209409C2779679107 @default.
- W2337209409 hasConceptScore W2337209409C2779770810 @default.
- W2337209409 hasConceptScore W2337209409C2780559512 @default.
- W2337209409 hasConceptScore W2337209409C538909803 @default.
- W2337209409 hasConceptScore W2337209409C55493867 @default.
- W2337209409 hasConceptScore W2337209409C71924100 @default.
- W2337209409 hasIssue "2" @default.
- W2337209409 hasLocation W23372094091 @default.
- W2337209409 hasOpenAccess W2337209409 @default.
- W2337209409 hasPrimaryLocation W23372094091 @default.
- W2337209409 hasRelatedWork W1978005053 @default.
- W2337209409 hasRelatedWork W1992020086 @default.
- W2337209409 hasRelatedWork W2000320100 @default.
- W2337209409 hasRelatedWork W2044882043 @default.
- W2337209409 hasRelatedWork W2051346378 @default.
- W2337209409 hasRelatedWork W2093039594 @default.
- W2337209409 hasRelatedWork W2141970258 @default.
- W2337209409 hasRelatedWork W2337209409 @default.
- W2337209409 hasRelatedWork W2338666212 @default.
- W2337209409 hasRelatedWork W2362338892 @default.
- W2337209409 hasVolume "32" @default.
- W2337209409 isParatext "false" @default.
- W2337209409 isRetracted "false" @default.
- W2337209409 magId "2337209409" @default.
- W2337209409 workType "article" @default.