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- W2337223096 abstract "Introduction and objectives IPF is a progressive, irreversible and fatal disease. Early treatment initiation when lung function is relatively preserved may have beneficial outcomes; however, published data to support this hypothesis are lacking. We investigated the efficacy of pirfenidone at 12 months in patients stratified by lung function using forced vital capacity (FVC) or GAP stage. Methods Efficacy outcomes (FVC, 6-minute walk distance [6MWD] and dyspnea [UCSD SOBQ]) were analysed at 12 months in patients randomised to pirfenidone 2403 mg/d or placebo in the pooled CAPACITY/ASCEND population (N = 1247), stratified by baseline FVC (≥80%, Results Demographic characteristics were similar across all four groups. In the placebo arm, disease progression as measured by FVC occurred with comparable frequency in patients with FVC ≥80% and FVC vs more preserved lung function was comparable, with no significant treatment-by subgroup interaction (Figure 1). Conclusions In the placebo population, clinically significant disease progression occurs in subgroups with more and less preserved lung function at baseline, underlying the need for early intervention. The magnitude of pirfenidone treatment effect on functional measures was comparable in these subgroups of patients (FVC vs FVC ≥80% or GAP I vs GAP II-III stage), supporting the initiation of treatment soon after diagnosis, when pulmonary function is relatively preserved." @default.
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- W2337223096 date "2015-11-12" @default.
- W2337223096 modified "2023-10-01" @default.
- W2337223096 title "P14 Pirfenidone is efficacious in patients with idiopathic pulmonary fibrosis (IPF) with more preserved lung function" @default.
- W2337223096 doi "https://doi.org/10.1136/thoraxjnl-2015-207770.151" @default.
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