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• W2337228375 abstract "18F-AV-1451 is a PET tracer in development for assessment of neurofibrillary tau pathology. Understanding the relationship of tau pathology in Alzheimer's Disease (AD) to disease stage or exploring longitudinal changes in 18F-AV-1451 uptake may require quantitation of various aspects of tracer distribution including amplitude, extent and laterality of regional tracer distribution. PET scans were acquired 80-100 min post injection of 18F-AV-1451 in 154 subjects: 14 young healthy controls (YCN), 34 healthy older controls (OCN), 72 with mild cognitive impairment (MCI) and 34 with diagnosis of AD. Florbetapir PET was obtained to establish amyloid positivity (Aβ+). 18F-AV-1451 SUV ratios (SUVr) were calculated on a voxel-wise basis and for AAL regions across neocortical and mesial temporal lobe regions. Voxel-wise methods employed intensity-, extent- and laterality-based metrics. Regional and voxel-wise quantitative measures from PET images were evaluated across diagnostic group and amyloid status (Aβ+/-). Finally, SUVr images were entered into a multi-block barycentric discriminant analysis (MUBADA) to identify regions showing maximal diagnostic group discrimination (OCN, MCI AD and Aβ+ vs. Aβ- subgroups). Analyses showed mean differences between diagnostic groups for all approaches. Effect size (Cohen's D) for distinguishing cohorts was generally greater for extent than intensity metrics (e.g., ∼2.5 for extent metrics and ∼1.8 for intensity for distinguishing impairment). Asymmetry of tracer distribution (left > right) was common and more pronounced in MCI than in AD. MUBADA identified 2 dimensions, with the first of these characterized by increased retention in posterior neocortex (accounting for > 95% of the variance in regional SUVr pattern) and differentiated Aβ+ MCI and AD relative to all other groups. Regional and composite analyses were effective in discriminating cohorts divided by cognitive impairment severity and amyloid positivity. Voxel-based analyses appeared to provide further sensitivity to patterns of laterality and extent of involvement. Future studies will evaluate which methods are most sensitive to change over time. Extent and Intensity Metrics separate groups; laterality indices indicate left- dominant tracer uptake; voxels wise correlations demonstrate regional relationships to cognitive function, and discriminant analyses identify regions predominantly associated with distinguishing Aβ+ AD and MCI subieets from other cohorts." @default.
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• W2337228375 date "2015-07-01" @default.
• W2337228375 modified "2023-10-16" @default.
• W2337228375 title "IC-P-165: Understanding the topology of 18 F-AV-1451 (also known as T807) PET tau images in Alzheimer's disease" @default.
• W2337228375 doi "https://doi.org/10.1016/j.jalz.2015.06.188" @default.
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