Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337243072> ?p ?o ?g. }
- W2337243072 endingPage "2236" @default.
- W2337243072 startingPage "2228" @default.
- W2337243072 abstract "Pseudouridylation of messenger RNA emerges as an abundant modification involved in gene expression regulation. Pseudouridylation of stop codons in eukaryotic and bacterial cells results in stop-codon read through. The structural mechanism of this phenomenon is not known. Here we present a 3.1-Å crystal structure of Escherichia coli release factor 1 (RF1) bound to the 70S ribosome in response to the ΨAA codon. The structure reveals that recognition of a modified stop codon does not differ from that of a canonical stop codon. Our in vitro biochemical results support this finding by yielding nearly identical rates for peptide release from E. coli ribosomes programmed with pseudouridylated and canonical stop codons. The crystal structure also brings insight into E. coli RF1-specific interactions and suggests involvement of L27 in bacterial translation termination. Our results are consistent with a mechanism in which read through of a pseudouridylated stop codon in bacteria results from increased decoding by near-cognate tRNAs (miscoding) rather than from decreased efficiency of termination." @default.
- W2337243072 created "2016-06-24" @default.
- W2337243072 creator A5004824396 @default.
- W2337243072 creator A5007195869 @default.
- W2337243072 creator A5086024663 @default.
- W2337243072 date "2016-05-01" @default.
- W2337243072 modified "2023-10-12" @default.
- W2337243072 title "Structural Basis for Translation Termination on a Pseudouridylated Stop Codon" @default.
- W2337243072 cites W1195318580 @default.
- W2337243072 cites W1514642420 @default.
- W2337243072 cites W1521738036 @default.
- W2337243072 cites W1969681263 @default.
- W2337243072 cites W1979131204 @default.
- W2337243072 cites W1989067983 @default.
- W2337243072 cites W1990868071 @default.
- W2337243072 cites W1995017064 @default.
- W2337243072 cites W2001641653 @default.
- W2337243072 cites W2005005285 @default.
- W2337243072 cites W2012499642 @default.
- W2337243072 cites W2014056463 @default.
- W2337243072 cites W2020942151 @default.
- W2337243072 cites W2022754910 @default.
- W2337243072 cites W2026358434 @default.
- W2337243072 cites W2026384929 @default.
- W2337243072 cites W2032279044 @default.
- W2337243072 cites W2041188328 @default.
- W2337243072 cites W2059222613 @default.
- W2337243072 cites W2062814567 @default.
- W2337243072 cites W2063647838 @default.
- W2337243072 cites W2081893178 @default.
- W2337243072 cites W2085928743 @default.
- W2337243072 cites W2088873069 @default.
- W2337243072 cites W2094113855 @default.
- W2337243072 cites W2097857247 @default.
- W2337243072 cites W2101404563 @default.
- W2337243072 cites W2105326796 @default.
- W2337243072 cites W2106290432 @default.
- W2337243072 cites W2108959691 @default.
- W2337243072 cites W2109184569 @default.
- W2337243072 cites W2112089152 @default.
- W2337243072 cites W2117291177 @default.
- W2337243072 cites W2130365538 @default.
- W2337243072 cites W2147981074 @default.
- W2337243072 cites W2150085257 @default.
- W2337243072 cites W2152301430 @default.
- W2337243072 cites W2159131581 @default.
- W2337243072 cites W2161890613 @default.
- W2337243072 cites W2169147815 @default.
- W2337243072 cites W2172357808 @default.
- W2337243072 cites W2186864552 @default.
- W2337243072 cites W2269683575 @default.
- W2337243072 cites W2284316917 @default.
- W2337243072 cites W318165075 @default.
- W2337243072 cites W4248872320 @default.
- W2337243072 doi "https://doi.org/10.1016/j.jmb.2016.04.018" @default.
- W2337243072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5017060" @default.
- W2337243072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27107638" @default.
- W2337243072 hasPublicationYear "2016" @default.
- W2337243072 type Work @default.
- W2337243072 sameAs 2337243072 @default.
- W2337243072 citedByCount "29" @default.
- W2337243072 countsByYear W23372430722016 @default.
- W2337243072 countsByYear W23372430722017 @default.
- W2337243072 countsByYear W23372430722018 @default.
- W2337243072 countsByYear W23372430722019 @default.
- W2337243072 countsByYear W23372430722020 @default.
- W2337243072 countsByYear W23372430722021 @default.
- W2337243072 countsByYear W23372430722022 @default.
- W2337243072 countsByYear W23372430722023 @default.
- W2337243072 crossrefType "journal-article" @default.
- W2337243072 hasAuthorship W2337243072A5004824396 @default.
- W2337243072 hasAuthorship W2337243072A5007195869 @default.
- W2337243072 hasAuthorship W2337243072A5086024663 @default.
- W2337243072 hasBestOaLocation W23372430721 @default.
- W2337243072 hasConcept C104317684 @default.
- W2337243072 hasConcept C105580179 @default.
- W2337243072 hasConcept C114847915 @default.
- W2337243072 hasConcept C141231307 @default.
- W2337243072 hasConcept C149364088 @default.
- W2337243072 hasConcept C153957851 @default.
- W2337243072 hasConcept C167625842 @default.
- W2337243072 hasConcept C176990463 @default.
- W2337243072 hasConcept C20580545 @default.
- W2337243072 hasConcept C2779498050 @default.
- W2337243072 hasConcept C47289529 @default.
- W2337243072 hasConcept C54355233 @default.
- W2337243072 hasConcept C67705224 @default.
- W2337243072 hasConcept C86803240 @default.
- W2337243072 hasConcept C87253356 @default.
- W2337243072 hasConcept C88478588 @default.
- W2337243072 hasConceptScore W2337243072C104317684 @default.
- W2337243072 hasConceptScore W2337243072C105580179 @default.
- W2337243072 hasConceptScore W2337243072C114847915 @default.
- W2337243072 hasConceptScore W2337243072C141231307 @default.
- W2337243072 hasConceptScore W2337243072C149364088 @default.
- W2337243072 hasConceptScore W2337243072C153957851 @default.
- W2337243072 hasConceptScore W2337243072C167625842 @default.
- W2337243072 hasConceptScore W2337243072C176990463 @default.