FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337248021> ?p ?o ?g. }

• W2337248021 endingPage "402" @default.
• W2337248021 startingPage "397" @default.
• W2337248021 abstract "Radiolabeled Exendin-4, a synthetic glucagon-like peptide-1 (GLP-1) analog, is used as a tracer for diagnostic purposes of β-cells and in experimental animal research. Exendin-4 can be radiolabeled with (68)Ga, (111)In or (99m)Tc and used for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging to diagnose insulinomas, visualization of pancreatic β-cell mass and transplanted Islets of Langerhans. In humans, Exendin-4 is widely used as a therapeutic agent for treatment of type 2 diabetes (T2D). The compound, which is administered subcutaneously (SC) may cause nausea, vomiting and a minor increase in the heart rate (HR). However, possible side-effects on cardiovascular functions after intravenous (IV) administration have not been reported. This study describes the Exendin-4 dose at which cardiovascular side-effects occur in pigs and cynomolgus monkeys. The IV effect of the tracer on insulin secretion is also investigated in pigs.Seven clinically healthy littermate pigs (40days old) were used; three of them were made diabetic by streptozotocin (STZ). All pigs underwent PET imaging under general anesthesia to examine the glucagon-like peptide-1 receptor (GLP-1R) in β-cells with radiolabeled Exendin-4. A baseline tracer dose IV [(68)Ga]Exendin-4 (0.025±0.010μg/kg) followed by a competition dose IV [(68)Ga]Exendin-4 (3.98±1.33μg/kg) 60min later were administered. Blood samples were taken and analyzed for insulin secretion by using ELISA. Cardiovascular and respiratory variables were monitored throughout the experiment.Immediately after administration of the high dose [(68)Ga]Exendin-4 the HR rose from 122±14 to 227±40bpm (p<0.01) and from 100±5 to 181±13bpm (p<0.01) in healthy non-diabetic and diabetes-induced pigs, respectively. The tachycardia was observed for >2h and one healthy non-diabetic pig suffered cardiac arrest 3h after the IV [(68)Ga]Exendin-4. Arrhythmia was detected by listening to the heart with a stethoscope up to 4days after the [(68)Ga]Exendin-4 injection. In all animals, no effect on the cardiovascular system was registered after the low dose of IV [(68)Ga]Exendin-4. Insulin secretion increased (p<0.05) when IV [(68)Ga]Exendin-4 was given in dosages ≥0.14μg/kg.Intravenous administration of ≥2.8μg/kg [(68)Ga]Exendin-4 resulted in severe tachycardia and arrhythmias in healthy non-diabetic and diabetes-induced pigs, and the insulin secretion was stimulated in healthy non-diabetic animals when ≥0.14μg/kg [(68)Ga]Exendin-4 was given." @default.
• W2337248021 created "2016-06-24" @default.
• W2337248021 creator A5028668242 @default.
• W2337248021 creator A5029535057 @default.
• W2337248021 creator A5052726269 @default.
• W2337248021 creator A5053292861 @default.
• W2337248021 creator A5054725620 @default.
• W2337248021 creator A5055673489 @default.
• W2337248021 creator A5080025418 @default.
• W2337248021 date "2016-07-01" @default.
• W2337248021 modified "2023-09-23" @default.
• W2337248021 title "Cardiovascular side-effects and insulin secretion after intravenous administration of radiolabeled Exendin-4 in pigs" @default.
• W2337248021 cites W1979288606 @default.
• W2337248021 cites W2009257151 @default.
• W2337248021 cites W2012005695 @default.
• W2337248021 cites W2018666069 @default.
• W2337248021 cites W2023644010 @default.
• W2337248021 cites W2028867924 @default.
• W2337248021 cites W2038335142 @default.
• W2337248021 cites W2063255837 @default.
• W2337248021 cites W2070027753 @default.
• W2337248021 cites W2102393399 @default.
• W2337248021 cites W2104818363 @default.
• W2337248021 cites W2107294913 @default.
• W2337248021 cites W2107949845 @default.
• W2337248021 cites W2109677274 @default.
• W2337248021 cites W2116553674 @default.
• W2337248021 cites W2124016563 @default.
• W2337248021 cites W2135112988 @default.
• W2337248021 cites W2138077952 @default.
• W2337248021 cites W2139672190 @default.
• W2337248021 cites W2145962263 @default.
• W2337248021 cites W2150137315 @default.
• W2337248021 cites W2150607504 @default.
• W2337248021 cites W2262303485 @default.
• W2337248021 cites W2314053370 @default.
• W2337248021 cites W2320222570 @default.
• W2337248021 cites W2333302658 @default.
• W2337248021 cites W4252795044 @default.
• W2337248021 doi "https://doi.org/10.1016/j.nucmedbio.2016.04.002" @default.
• W2337248021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27179248" @default.
• W2337248021 hasPublicationYear "2016" @default.
• W2337248021 type Work @default.
• W2337248021 sameAs 2337248021 @default.
• W2337248021 citedByCount "11" @default.
• W2337248021 countsByYear W23372480212017 @default.
• W2337248021 countsByYear W23372480212018 @default.
• W2337248021 countsByYear W23372480212019 @default.
• W2337248021 countsByYear W23372480212020 @default.
• W2337248021 countsByYear W23372480212021 @default.
• W2337248021 countsByYear W23372480212022 @default.
• W2337248021 crossrefType "journal-article" @default.
• W2337248021 hasAuthorship W2337248021A5028668242 @default.
• W2337248021 hasAuthorship W2337248021A5029535057 @default.
• W2337248021 hasAuthorship W2337248021A5052726269 @default.
• W2337248021 hasAuthorship W2337248021A5053292861 @default.
• W2337248021 hasAuthorship W2337248021A5054725620 @default.
• W2337248021 hasAuthorship W2337248021A5055673489 @default.
• W2337248021 hasAuthorship W2337248021A5080025418 @default.
• W2337248021 hasConcept C126322002 @default.
• W2337248021 hasConcept C134018914 @default.
• W2337248021 hasConcept C2775842073 @default.
• W2337248021 hasConcept C2776398474 @default.
• W2337248021 hasConcept C2777180221 @default.
• W2337248021 hasConcept C2779280383 @default.
• W2337248021 hasConcept C2779306644 @default.
• W2337248021 hasConcept C2780580376 @default.
• W2337248021 hasConcept C2780852908 @default.
• W2337248021 hasConcept C2989005 @default.
• W2337248021 hasConcept C555293320 @default.
• W2337248021 hasConcept C71924100 @default.
• W2337248021 hasConceptScore W2337248021C126322002 @default.
• W2337248021 hasConceptScore W2337248021C134018914 @default.
• W2337248021 hasConceptScore W2337248021C2775842073 @default.
• W2337248021 hasConceptScore W2337248021C2776398474 @default.
• W2337248021 hasConceptScore W2337248021C2777180221 @default.
• W2337248021 hasConceptScore W2337248021C2779280383 @default.
• W2337248021 hasConceptScore W2337248021C2779306644 @default.
• W2337248021 hasConceptScore W2337248021C2780580376 @default.
• W2337248021 hasConceptScore W2337248021C2780852908 @default.
• W2337248021 hasConceptScore W2337248021C2989005 @default.
• W2337248021 hasConceptScore W2337248021C555293320 @default.
• W2337248021 hasConceptScore W2337248021C71924100 @default.
• W2337248021 hasIssue "7" @default.
• W2337248021 hasLocation W23372480211 @default.
• W2337248021 hasLocation W23372480212 @default.
• W2337248021 hasOpenAccess W2337248021 @default.
• W2337248021 hasPrimaryLocation W23372480211 @default.
• W2337248021 hasRelatedWork W1976841804 @default.
• W2337248021 hasRelatedWork W1999373161 @default.
• W2337248021 hasRelatedWork W2003485540 @default.
• W2337248021 hasRelatedWork W2056069628 @default.
• W2337248021 hasRelatedWork W2094002640 @default.
• W2337248021 hasRelatedWork W2112457773 @default.
• W2337248021 hasRelatedWork W2131147582 @default.
• W2337248021 hasRelatedWork W2151200778 @default.
• W2337248021 hasRelatedWork W2434287781 @default.
• W2337248021 hasRelatedWork W4240404135 @default.

• next