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• W2337262804 abstract "Studies dating back to the 1970s established that binding between the anti-Shine-Dalgarno (aSD) sequence on prokaryotic ribosomes and mRNA helps to facilitate translation initiation. The location of aSD binding relative to the start codon, the full extents of the aSD sequence, and the functional form of the relationship between aSD binding and translation efficiency are important parameters that remain ill defined in the literature. Here, we leverage genome-wide estimates of translation efficiency to determine these parameters and show that anti-Shine-Dalgarno sequence binding increases the translation of endogenous mRNAs on the order of 50%. Our findings highlight the non-linearity of this relationship, showing that translation efficiency is maximized for sequences with intermediate aSD binding strengths. These mechanistic insights are highly robust; we find nearly identical results in ribosome profiling datasets from 3 highly diverged bacteria, as well as independent genome-scale estimates and controlled experimental data using recombinant GFP expression." @default.
• W2337262804 created "2016-06-24" @default.
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• W2337262804 date "2016-02-06" @default.
• W2337262804 modified "2023-10-04" @default.
• W2337262804 title "Defining the anti-Shine-Dalgarno sequence interaction and quantifying its functional role in regulating translation efficiency" @default.
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• W2337262804 doi "https://doi.org/10.1101/038984" @default.
• W2337262804 hasPublicationYear "2016" @default.
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