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• W2337263724 endingPage "27448" @default.
• W2337263724 startingPage "27440" @default.
• W2337263724 abstract "Conducting polymers possessing biorecognition elements are essential for developing electrical biosensors sensitive and specific to clinically relevant biomolecules. We developed a new 3,4-ethylenedioxythiophene (EDOT) derivative bearing a zwitterionic phosphorylcholine group via a facile synthesis through the Michael-type addition thiol–ene “click” reaction for the detection of an acute-phase biomarker human C-reactive protein (CRP). The phosphorylcholine group, a major headgroup in phospholipid, which is the main constituent of plasma membrane, was also expected to resist nonspecific adsorption of other proteins at the electrode/solution interface. The biomimetic EDOT derivative was randomly copolymerized with EDOT, via an electropolymerization technique with a dopant sodium perchlorate, onto a glassy carbon electrode to make the synthesized polymer film both conductive and target-responsive. The conducting copolymer films were characterized by cyclic voltammetry, scanning electron microscopy, attenuated total reflection Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy. The specific interaction of CRP with phosphorylcholine in a calcium-containing buffer solution was determined by differential pulse voltammetry, which measures the altered redox reaction between the indicators ferricyanide/ferrocyanide as a result of the binding event. The conducting polymer-based protein sensor achieved a limit of detection of 37 nM with a dynamic range of 10–160 nM, covering the dynamically changing CRP levels in circulation during the acute phase. The results will enable the development of metal-free, antibody-free, and low-impedance electrochemical biosensors for the screening of nonspecific biomarkers of inflammation and infection." @default.
• W2337263724 created "2016-06-24" @default.
• W2337263724 creator A5000998032 @default.
• W2337263724 creator A5006788784 @default.
• W2337263724 creator A5038738931 @default.
• W2337263724 creator A5081523660 @default.
• W2337263724 date "2015-12-02" @default.
• W2337263724 modified "2023-10-02" @default.
• W2337263724 title "Poly(3,4-ethylenedioxythiophene) Bearing Phosphorylcholine Groups for Metal-Free, Antibody-Free, and Low-Impedance Biosensors Specific for C-Reactive Protein" @default.
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• W2337263724 doi "https://doi.org/10.1021/acsami.5b09325" @default.
• W2337263724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26588324" @default.
• W2337263724 hasPublicationYear "2015" @default.
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