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• W2337295910 abstract "We investigated electrophysiological properties of human induced-pluripotent-stem-cell-derived and embryonic-stem-cell-derived cardiomyocytes, and analyzed action potential parameters by plotting their frequency distributions. In the both cell lines, the distribution analysis revealed that histograms of maximum upstroke velocity showed two subpopulations with similar intersection values. Sub-populations with faster maximum upstroke velocity showed significant prolongation of action potential durations by application of E-4031, whereas others did not, which may be partly due to shallower maximum diastolic potentials. We described electrophysiological and pharmacological properties of stem-cell-derived cardiomyocytes in the respective sub-populations, which provides a way to characterize diverse electrical properties of stem-cell-derived cardiomyocytes systematically." @default.
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• W2337295910 date "2016-06-01" @default.
• W2337295910 modified "2023-09-25" @default.
• W2337295910 title "A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes" @default.
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• W2337295910 doi "https://doi.org/10.1016/j.jphs.2016.04.015" @default.
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