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- W2337299811 abstract "目的建立高效液相色谱-串联质谱（LC-MS/MS）法测定大鼠血浆中阿魏酸的血药质量浓度。方法色谱柱采用Diamonsil C18柱（150 mm×4.6 mm,5μm）,仪器采用API 4000三重四极杆串联质谱仪,采用多反应监测（multiple reaction monitoring,MRM）扫描方式检测,采用沉淀蛋白法处理样品,用于定量分析的离子对为m/z 193.1→m/z 134.1（阿魏酸）和m/z 121.2→m/z 77.0（苯甲酸,内标）。结果该方法的线性范围在5.0～2 000.0μg.L-1,定量下限为5.0μg.L-1,且血浆中内源性物质不干扰阿魏酸的测定;日内和日间精密度RSD均小于15%;阿魏酸的平均提取回收率为91.0%～100.5%,基质效应在87.8%～89.7%。结论该方法适用于阿魏酸在大鼠体内的药物动力学研究。" @default.
- W2337299811 created "2016-06-24" @default.
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- W2337299811 date "2013-01-01" @default.
- W2337299811 modified "2023-09-28" @default.
- W2337299811 title "LC-MS/MS法测定大鼠血浆中阿魏酸的血药浓度" @default.
- W2337299811 hasPublicationYear "2013" @default.
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