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• W2337311909 abstract "Polycystic ovary syndrome (PCOS) is an endocrine disorder, which affects women at reproductive age. Syndrome is characterized by hyperandrogenism, polycystic ovarian morphology and ovulatory dysfunction. PCOS is associated with reproductive and metabolic abnormalities including infertility, insulin resistance and type 2 diabetes. Prevalence of PCOS changes by the used diagnostic criteria for PCOS. According to ESHRE / ASRM (European Society of Human Reproduction and Embryology / American Society for Reproductive Medicine) criteria PCOS is diagnosed at nearly 15%-20% of women. Adult women, who have type 1-2 diabetes, are under high risk of PCOS. 50%-70% of PCOS patients have insulin resistance. Diseases like hypertension, dyslipidemia, glucose intolerance, diabetes are highly associated with insulin resistance and PCOS. In addition, hirsutism and menstrual irregularities could occur with PCOS. Studies show that there is a relation between PCOS and cardiovascular diseases and cancer as well. Studies identified that mental disorders (depression, anxiety, bipolar disorder and binge eating disorder) are frequently seen at PCOS patients. The treatment strategies applied to PCOS patients vary according to the hormonal status and profile of the patient. Clomiphene citrate-metformin therapy, fertility treatments, laparoscopic ovarian surgery or gonadotrophin hormone therapy are the most frequent therapies used for treatment of PCOS. PCOS is a complex disorder, which includes metabolic, endocrinologic, psychiatric and cardiovascular effects. These effects could be lifetime long and OZET Polikistik over sendromu (PKOS), ureme cagindaki kadinlari etkileyen bir endokrin hastaligidir. Sendrom polikistik over morfolojisi, kronik yumurtlama bozuklugu ve androjen hormonlarin artisiyla karakterizedir ve basta infertilite olmak uzere insulin direnci ve tip 2 diyabet gibi hastaliklarla da dogrudan iliskilidir. PKOS’un gorulme sikligi kullanilan tani kriterlerine gore degisiklik gostermektedir. ESHRE / ASRM (Insan Uremesi ve Embriyolojisi Avrupa Toplulugu / Amerika Ureme Tibbi Dernegi) kriterlerine gore her 100 kadindan yaklasik 15-20’sine PKOS teshisi konmaktadir. Tip 1-2 diyabet hastasi yetiskin kadinlar PKOS acisindan risk altindadirlar. PKOS hastasi kadinlarin %50-70’inde insulin direnci ve bu duruma bagli olarak gelisebilen hipertansiyon, dislipidemi, glikoz intoleransi, diyabet gibi hastaliklar gelismektedir. Killanma (hirsutism) ve adet dongusu duzensizlikleri de yine PKOS ile birlikte gorulebilmektedir. Yapilan calismalarda, PKOS’un kardiyovaskuler hastaliklar ve kanser gibi hastaliklarla iliskisi de gosterilmistir. Yine mental duzensizliklerin de (depresyon, kaygi bozuklugu, bipolar bozukluk ve tikanircasina yeme bozuklugu) PKOS hastasi kadinlarda daha sik goruldugu tespit edilmistir. PKOS’ta hormonal duruma ve hasta profiline gore degisen klomifen sitrat-metformin terapisi, uremeye yardimci tedaviler, laparoskopik ovaryum cerrahisi veya disaridan gonadotropin verilmesi gibi tedavi yontemleri uygulanmaktadir. Polikistik over sendromu metabolik, endokrinolojik, psikiyatrik ve kardiyovaskuler etkileri ile kompleks bir hastaliktir. Etkileri hastalarin hayati boyunca surebilmekte ve 1 Ankara Universitesi, Biyoteknoloji Enstitusu, ANKARA Gelis Tarihi / Received : Kabul Tarihi / Accepted : Iletisim / Corresponding Author : Bala GUR-DEDEOĞLU Ankara Universitesi, Biyoteknoloji Enstitusu, ANKARA Tel : +90 312 222 58 26-124 E-posta / E-mail : gurbala@yahoo.com 14.10.2014 09.02.2015 DOI ID : 10.5505/TurkHijyen.2016.09327 Turk Hijyen ve Deneysel Biyoloji Dergisi Aydos A, Oztemur Y, Gur-Dedeoglu B. Polikistik over sendromu ve molekuler yaklasimlar. Turk Hij Den Biyol Derg, 2016; 73(1): 81-8. Makale Dili “Turkce”/Article Language “Turkish”" @default.
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• W2337311909 title "Polycystic ovary syndrome and molecular approaches" @default.
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