FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337332359> ?p ?o ?g. }

• W2337332359 abstract "Atherosclerosis is a condition that involves multiple pathophysiological mechanisms and whose knowledge has not been fully elucidated. Often, scientific advances on the atherogenic pathophysiology generate that molecules not previously considered in the scene of this disease, were attributed actions on the onset or progression of it. A representative example is the study of a new mechanism involved in the atherogenic process, consisting of the association between the insulin-like growth factor (IGF) system and pregnancy-associated plasma protein-A (PAPP-A). Insulin-like growth factor system is a family of peptides that include 3 peptide hormones, 4 transmembrane receptors and 6 binding proteins. Insulin-like growth factor-1 (IGF-1) is the main ligand of the IGF system involved in coronary atherosclerosis. IGF-1 exerts its effects via activation of the IGF-1R receptor on vascular smooth muscle cells or macrophages. In vascular smooth muscle cells promotes migration and prevents apoptosis which increases plaque stability while in macrophages reduces reverse cholesterol transport leading to the formation of foam cells. Regulation of IGF-1 endothelial bioavailability is carried out by IGFBP proteases, mainly by PAPP-A. In this review, we address the mechanisms between IGF system and PAPP-A in atherosclerosis with emphasis on molecular effects on vascular smooth muscle cells and macrophages." @default.
• W2337332359 created "2016-06-24" @default.
• W2337332359 creator A5003396073 @default.
• W2337332359 creator A5045934639 @default.
• W2337332359 creator A5060191525 @default.
• W2337332359 creator A5064632192 @default.
• W2337332359 creator A5065529255 @default.
• W2337332359 creator A5073961738 @default.
• W2337332359 creator A5090375947 @default.
• W2337332359 date "2016-04-01" @default.
• W2337332359 modified "2023-09-27" @default.
• W2337332359 title "Asociación entre el sistema IGF y PAPP-A en ateroesclerosis coronaria" @default.
• W2337332359 cites W103954886 @default.
• W2337332359 cites W1488424161 @default.
• W2337332359 cites W1558459060 @default.
• W2337332359 cites W1616845142 @default.
• W2337332359 cites W1693095142 @default.
• W2337332359 cites W1731510796 @default.
• W2337332359 cites W1870719661 @default.
• W2337332359 cites W1963563782 @default.
• W2337332359 cites W1972087461 @default.
• W2337332359 cites W1972949410 @default.
• W2337332359 cites W1973373900 @default.
• W2337332359 cites W1976299678 @default.
• W2337332359 cites W1981034985 @default.
• W2337332359 cites W1983314720 @default.
• W2337332359 cites W1991705367 @default.
• W2337332359 cites W1994491528 @default.
• W2337332359 cites W1997387804 @default.
• W2337332359 cites W1997620569 @default.
• W2337332359 cites W1998245838 @default.
• W2337332359 cites W1999435652 @default.
• W2337332359 cites W2000132670 @default.
• W2337332359 cites W2000499358 @default.
• W2337332359 cites W2000594342 @default.
• W2337332359 cites W2001359587 @default.
• W2337332359 cites W2001608630 @default.
• W2337332359 cites W2007163552 @default.
• W2337332359 cites W2007217993 @default.
• W2337332359 cites W2009879726 @default.
• W2337332359 cites W2011449660 @default.
• W2337332359 cites W2011773115 @default.
• W2337332359 cites W2013041603 @default.
• W2337332359 cites W2018151362 @default.
• W2337332359 cites W2020235333 @default.
• W2337332359 cites W2020677035 @default.
• W2337332359 cites W2023751105 @default.
• W2337332359 cites W2023841557 @default.
• W2337332359 cites W2024707576 @default.
• W2337332359 cites W2039789208 @default.
• W2337332359 cites W2040828021 @default.
• W2337332359 cites W2042340279 @default.
• W2337332359 cites W2042693437 @default.
• W2337332359 cites W2045623677 @default.
• W2337332359 cites W2045982598 @default.
• W2337332359 cites W2046683525 @default.
• W2337332359 cites W2047054324 @default.
• W2337332359 cites W2048659949 @default.
• W2337332359 cites W2049247109 @default.
• W2337332359 cites W2050856345 @default.
• W2337332359 cites W2053018220 @default.
• W2337332359 cites W2059627527 @default.
• W2337332359 cites W2062783960 @default.
• W2337332359 cites W2062827887 @default.
• W2337332359 cites W2065212580 @default.
• W2337332359 cites W2067054347 @default.
• W2337332359 cites W2067818275 @default.
• W2337332359 cites W2077492625 @default.
• W2337332359 cites W2078095800 @default.
• W2337332359 cites W2078163029 @default.
• W2337332359 cites W2080289648 @default.
• W2337332359 cites W2082608938 @default.
• W2337332359 cites W2086495242 @default.
• W2337332359 cites W2087546957 @default.
• W2337332359 cites W2090123548 @default.
• W2337332359 cites W2093897309 @default.
• W2337332359 cites W2102546671 @default.
• W2337332359 cites W2107719587 @default.
• W2337332359 cites W2109325768 @default.
• W2337332359 cites W2115268091 @default.
• W2337332359 cites W2115914704 @default.
• W2337332359 cites W2116555510 @default.
• W2337332359 cites W2119330617 @default.
• W2337332359 cites W2120332364 @default.
• W2337332359 cites W2121573598 @default.
• W2337332359 cites W2121968060 @default.
• W2337332359 cites W2128512711 @default.
• W2337332359 cites W2130483595 @default.
• W2337332359 cites W2134853846 @default.
• W2337332359 cites W2136638612 @default.
• W2337332359 cites W2145397058 @default.
• W2337332359 cites W2145807537 @default.
• W2337332359 cites W2148307357 @default.
• W2337332359 cites W2149507979 @default.
• W2337332359 cites W2153954854 @default.
• W2337332359 cites W2155645904 @default.
• W2337332359 cites W3765645 @default.
• W2337332359 doi "https://doi.org/10.1016/j.acmx.2015.12.006" @default.
• W2337332359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26906607" @default.
• W2337332359 hasPublicationYear "2016" @default.

• next