FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337343241> ?p ?o ?g. }

• W2337343241 endingPage "586" @default.
• W2337343241 startingPage "582" @default.
• W2337343241 abstract "To explore the role of the abnormal expression of miRNAs in the development process of non-small cell lung cancer and the feasibility of ultrasound microbubble-mediated gene therapy after transfecting antisense miRNA-224 and miRNA-122a plasmids into non-small cell lung cancer A549 cells.Antisense miRNA-224 and miRNA-122a plasmids were transfected into non-small cell lung cancer A549 cells on the optimal ultrasound microbubble-mediated condition. We set up a control group. The cell proliferation activity, apoptosis, invasion ability were detected by MTT assay, Annexin V-PE, Transwell invasion experiment and colony formation assay, respectively.The expression of miRNA-224 decreased and the expression of miRNA-122a rose after the plasmids of target genes were transfected into non-small cell lung cancer A549 cells, and there were significant differences when compared with those of the control group (P < 0.05). After the plasmids of target genes were transfected into A549 cells, the growth of antisense miRNA-224 and miRNA-122a were inhibited, and the differences were significant as compared with the control group (P < 0.05). Besides, the inhibition of miRNA-122a group was the most significant and there was statistically significant difference as compared with miRNA-224 group (t = -4.694, P = 0.009). After the plasmids of target genes were transfected into A549 cells, the proportion of apoptotic cells increased, the invasive cells were decreased and the clone ability reduced, and also there was a significant difference as compared with those of the control group (P < 0.05). What's more, the apoptotic peak appeared in miRNA-122a group. Its invasion ability decreased most obviously (40.25 ± 3.97/visual field), the number of clone ability was 104.93 ± 4.87 and the inhibitory effect was the most obviously. There was statistically significant difference as compared with other groups (P < 0.05).A549 cells transfected by ultrasound microbubble-mediated antisense miRNA-224 and miRNA-122a plasmids possessed good transfection efficiency. The cell growth, invasion and colony-forming abilities of transfected A549 cells were suppressed, which laid a solid foundation for the gene therapy of non-small cell lung cancer." @default.
• W2337343241 created "2016-06-24" @default.
• W2337343241 creator A5020957404 @default.
• W2337343241 creator A5059605240 @default.
• W2337343241 creator A5073277668 @default.
• W2337343241 creator A5089839891 @default.
• W2337343241 creator A5090859256 @default.
• W2337343241 date "2016-06-01" @default.
• W2337343241 modified "2023-10-14" @default.
• W2337343241 title "Correlation study of biological characteristics of non-small cell lung cancer A549 cells after transfecting plasmid by microbubble ultrasound contrast agent" @default.
• W2337343241 cites W2022192042 @default.
• W2337343241 cites W2029426792 @default.
• W2337343241 cites W2056577175 @default.
• W2337343241 cites W2066657193 @default.
• W2337343241 cites W2090305721 @default.
• W2337343241 cites W2132534801 @default.
• W2337343241 cites W2172658300 @default.
• W2337343241 cites W2173160239 @default.
• W2337343241 cites W2173911727 @default.
• W2337343241 cites W2176151029 @default.
• W2337343241 cites W2177009065 @default.
• W2337343241 cites W2181731478 @default.
• W2337343241 cites W2181772832 @default.
• W2337343241 cites W2182266844 @default.
• W2337343241 cites W2185526698 @default.
• W2337343241 cites W2186495104 @default.
• W2337343241 cites W2194875718 @default.
• W2337343241 cites W2195216866 @default.
• W2337343241 cites W2198066582 @default.
• W2337343241 cites W2409185593 @default.
• W2337343241 cites W2415825232 @default.
• W2337343241 doi "https://doi.org/10.1016/j.apjtm.2016.04.007" @default.
• W2337343241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27262071" @default.
• W2337343241 hasPublicationYear "2016" @default.
• W2337343241 type Work @default.
• W2337343241 sameAs 2337343241 @default.
• W2337343241 citedByCount "4" @default.
• W2337343241 countsByYear W23373432412017 @default.
• W2337343241 countsByYear W23373432412019 @default.
• W2337343241 countsByYear W23373432412021 @default.
• W2337343241 countsByYear W23373432412022 @default.
• W2337343241 crossrefType "journal-article" @default.
• W2337343241 hasAuthorship W2337343241A5020957404 @default.
• W2337343241 hasAuthorship W2337343241A5059605240 @default.
• W2337343241 hasAuthorship W2337343241A5073277668 @default.
• W2337343241 hasAuthorship W2337343241A5089839891 @default.
• W2337343241 hasAuthorship W2337343241A5090859256 @default.
• W2337343241 hasBestOaLocation W23373432411 @default.
• W2337343241 hasConcept C104317684 @default.
• W2337343241 hasConcept C111599444 @default.
• W2337343241 hasConcept C142724271 @default.
• W2337343241 hasConcept C145059251 @default.
• W2337343241 hasConcept C1491633281 @default.
• W2337343241 hasConcept C153911025 @default.
• W2337343241 hasConcept C190283241 @default.
• W2337343241 hasConcept C22744801 @default.
• W2337343241 hasConcept C2776256026 @default.
• W2337343241 hasConcept C502942594 @default.
• W2337343241 hasConcept C54009773 @default.
• W2337343241 hasConcept C54355233 @default.
• W2337343241 hasConcept C62112901 @default.
• W2337343241 hasConcept C71924100 @default.
• W2337343241 hasConcept C81089528 @default.
• W2337343241 hasConcept C81729549 @default.
• W2337343241 hasConcept C86803240 @default.
• W2337343241 hasConceptScore W2337343241C104317684 @default.
• W2337343241 hasConceptScore W2337343241C111599444 @default.
• W2337343241 hasConceptScore W2337343241C142724271 @default.
• W2337343241 hasConceptScore W2337343241C145059251 @default.
• W2337343241 hasConceptScore W2337343241C1491633281 @default.
• W2337343241 hasConceptScore W2337343241C153911025 @default.
• W2337343241 hasConceptScore W2337343241C190283241 @default.
• W2337343241 hasConceptScore W2337343241C22744801 @default.
• W2337343241 hasConceptScore W2337343241C2776256026 @default.
• W2337343241 hasConceptScore W2337343241C502942594 @default.
• W2337343241 hasConceptScore W2337343241C54009773 @default.
• W2337343241 hasConceptScore W2337343241C54355233 @default.
• W2337343241 hasConceptScore W2337343241C62112901 @default.
• W2337343241 hasConceptScore W2337343241C71924100 @default.
• W2337343241 hasConceptScore W2337343241C81089528 @default.
• W2337343241 hasConceptScore W2337343241C81729549 @default.
• W2337343241 hasConceptScore W2337343241C86803240 @default.
• W2337343241 hasIssue "6" @default.
• W2337343241 hasLocation W23373432411 @default.
• W2337343241 hasLocation W23373432412 @default.
• W2337343241 hasOpenAccess W2337343241 @default.
• W2337343241 hasPrimaryLocation W23373432411 @default.
• W2337343241 hasRelatedWork W2347272947 @default.
• W2337343241 hasRelatedWork W2349614559 @default.
• W2337343241 hasRelatedWork W2354729941 @default.
• W2337343241 hasRelatedWork W2369227601 @default.
• W2337343241 hasRelatedWork W2372283855 @default.
• W2337343241 hasRelatedWork W2383662580 @default.
• W2337343241 hasRelatedWork W2387393586 @default.
• W2337343241 hasRelatedWork W2407199152 @default.
• W2337343241 hasRelatedWork W2468860086 @default.
• W2337343241 hasRelatedWork W3031235810 @default.
• W2337343241 hasVolume "9" @default.

• next