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- W2337369609 endingPage "e1154641" @default.
- W2337369609 startingPage "e1154641" @default.
- W2337369609 abstract "The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability. However, such alterations are also involved in remodeling the brain endothelial cell surface and regulating brain endothelial cell phenotype. This review summarizes the characteristics of brain endothelial tight, adherens and gap junctions and highlights structural and functional alterations in junctional proteins that may contribute to BBB dysfunction." @default.
- W2337369609 created "2016-06-24" @default.
- W2337369609 creator A5003678910 @default.
- W2337369609 creator A5024720824 @default.
- W2337369609 creator A5078481859 @default.
- W2337369609 creator A5079130375 @default.
- W2337369609 date "2016-01-02" @default.
- W2337369609 modified "2023-10-10" @default.
- W2337369609 title "Junctional proteins of the blood-brain barrier: New insights into function and dysfunction" @default.
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