FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337375966> ?p ?o ?g. }

• W2337375966 endingPage "1203" @default.
• W2337375966 startingPage "1197" @default.
• W2337375966 abstract "This phase II trial evaluates, for the first time, the safety and efficacy of bendamustine plus high-dose melphalan (HDM) as a conditioning regimen before the second autologous stem cell transplantation (ASCT) in previously untreated multiple myeloma (MM) patients. In total, 32 ASCT patients received HDM (200 mg/m(2)) as conditioning for the first ASCT. After 3-6 months from the first ASCT, responding patients underwent a second ASCT following bendamustine (200 mg/m(2)) and HDM (140 mg/m(2)). High-dose chemotherapy and ASCT were performed with complete neutrophil and platelet recovery in all patients. The median number of days to neutrophil and platelet engraftment was 11 (range 9-15) and 12 (range 10-19), respectively. Only one subject experienced grade 3 diarrhea; the rate of mucositis and vomiting was significantly lower with the bendamustine plus HDM regimen compared with the HDM-only regimen (81.2 vs 96.9%, P=0.025 and 78.1 vs 100%, P=0.008). Overall response rate (ORR) was 81.2% after the first transplant, and 90.6% after the second, while complete response rates were 46.8 and 62.5%, respectively (P=0.016). Actuarial 2-year PFS and OS were 79% (95% confidence interval (CI), 60-98) and 97% (95% CI, 91-100), respectively. Bendamustine+HDM is feasible as the conditioning regimen for second ASCT in MM patients. The present study may pave the way for phase III studies specifically aimed at further investigating this combination strategy. The role of this combination in MM for conditioning regimen in a first or single ASCT setting should be also investigated." @default.
• W2337375966 created "2016-06-24" @default.
• W2337375966 creator A5000531020 @default.
• W2337375966 creator A5009797638 @default.
• W2337375966 creator A5013001610 @default.
• W2337375966 creator A5016021915 @default.
• W2337375966 creator A5022153283 @default.
• W2337375966 creator A5025049786 @default.
• W2337375966 creator A5032955393 @default.
• W2337375966 creator A5061896020 @default.
• W2337375966 creator A5086116060 @default.
• W2337375966 date "2016-04-18" @default.
• W2337375966 modified "2023-10-06" @default.
• W2337375966 title "A phase II, single-arm, prospective study of bendamustine plus melphalan conditioning for second autologous stem cell transplantation in de novo multiple myeloma patients through a tandem transplant strategy" @default.
• W2337375966 cites W1703963147 @default.
• W2337375966 cites W1975542133 @default.
• W2337375966 cites W1995310604 @default.
• W2337375966 cites W2001813071 @default.
• W2337375966 cites W2003920534 @default.
• W2337375966 cites W2006996657 @default.
• W2337375966 cites W2025020615 @default.
• W2337375966 cites W2039496823 @default.
• W2337375966 cites W2040298958 @default.
• W2337375966 cites W2042892109 @default.
• W2337375966 cites W2044436186 @default.
• W2337375966 cites W2055338149 @default.
• W2337375966 cites W2058038339 @default.
• W2337375966 cites W2069968835 @default.
• W2337375966 cites W2075032656 @default.
• W2337375966 cites W2084542540 @default.
• W2337375966 cites W2088765731 @default.
• W2337375966 cites W2090310344 @default.
• W2337375966 cites W2094333196 @default.
• W2337375966 cites W2101414374 @default.
• W2337375966 cites W2102591890 @default.
• W2337375966 cites W2107057207 @default.
• W2337375966 cites W2114396320 @default.
• W2337375966 cites W2123516278 @default.
• W2337375966 cites W2125721471 @default.
• W2337375966 cites W2127143739 @default.
• W2337375966 cites W2128084036 @default.
• W2337375966 cites W2133407492 @default.
• W2337375966 cites W2136256331 @default.
• W2337375966 cites W2138389659 @default.
• W2337375966 cites W2142019712 @default.
• W2337375966 cites W2143425592 @default.
• W2337375966 cites W2144588669 @default.
• W2337375966 cites W2146839046 @default.
• W2337375966 cites W2148672632 @default.
• W2337375966 cites W2152124092 @default.
• W2337375966 cites W2152333590 @default.
• W2337375966 cites W2156605829 @default.
• W2337375966 cites W219829516 @default.
• W2337375966 cites W2398713841 @default.
• W2337375966 cites W3145716452 @default.
• W2337375966 cites W4211037848 @default.
• W2337375966 cites W4236730981 @default.
• W2337375966 cites W4376542883 @default.
• W2337375966 doi "https://doi.org/10.1038/bmt.2016.94" @default.
• W2337375966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27088375" @default.
• W2337375966 hasPublicationYear "2016" @default.
• W2337375966 type Work @default.
• W2337375966 sameAs 2337375966 @default.
• W2337375966 citedByCount "24" @default.
• W2337375966 countsByYear W23373759662017 @default.
• W2337375966 countsByYear W23373759662018 @default.
• W2337375966 countsByYear W23373759662019 @default.
• W2337375966 countsByYear W23373759662020 @default.
• W2337375966 countsByYear W23373759662021 @default.
• W2337375966 countsByYear W23373759662022 @default.
• W2337375966 countsByYear W23373759662023 @default.
• W2337375966 crossrefType "journal-article" @default.
• W2337375966 hasAuthorship W2337375966A5000531020 @default.
• W2337375966 hasAuthorship W2337375966A5009797638 @default.
• W2337375966 hasAuthorship W2337375966A5013001610 @default.
• W2337375966 hasAuthorship W2337375966A5016021915 @default.
• W2337375966 hasAuthorship W2337375966A5022153283 @default.
• W2337375966 hasAuthorship W2337375966A5025049786 @default.
• W2337375966 hasAuthorship W2337375966A5032955393 @default.
• W2337375966 hasAuthorship W2337375966A5061896020 @default.
• W2337375966 hasAuthorship W2337375966A5086116060 @default.
• W2337375966 hasBestOaLocation W23373759661 @default.
• W2337375966 hasConcept C126322002 @default.
• W2337375966 hasConcept C141071460 @default.
• W2337375966 hasConcept C2776364478 @default.
• W2337375966 hasConcept C2776694085 @default.
• W2337375966 hasConcept C2778496288 @default.
• W2337375966 hasConcept C2778684742 @default.
• W2337375966 hasConcept C2779050716 @default.
• W2337375966 hasConcept C2779338263 @default.
• W2337375966 hasConcept C2780653079 @default.
• W2337375966 hasConcept C2781413609 @default.
• W2337375966 hasConcept C2781442060 @default.
• W2337375966 hasConcept C2911091166 @default.
• W2337375966 hasConcept C31760486 @default.
• W2337375966 hasConcept C71924100 @default.
• W2337375966 hasConceptScore W2337375966C126322002 @default.
• W2337375966 hasConceptScore W2337375966C141071460 @default.

• next