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- W2337394083 endingPage "12" @default.
- W2337394083 startingPage "S" @default.
- W2337394083 abstract "Genetic alterations, including gene mutations, and chromosomal amplifications, deletions, inversions, and translocations, are hallmarks of the molecular biology of cancer. These events lead to oncogene activation, formation of chimeric oncoproteins, and/or inactivation of tumor suppressor genes. Such genetic changes contribute to the neoplastic transformation of cells, as well as the eventual acquisition by malignant cells of a more aggressive biologic and clinical behavior. However, in recent years, it has become apparent that these genetic events are not the sole determinants of the biologic behavior of tumor cells. Indeed, it is becoming increasingly apparent that tumor cells with a given genotype exhibit a differential phenotype depending on the microenvironment in which they reside. Furthermore, extensive data have shown that derivative daughter cells of neoplastic, as well as normal cells, inherit changes in the patterns of gene expression that are not associated with changes in the primary DNA sequence but are instead related to changes in chromatin structure and its accessibility for transcriptional activity. These heritable gene expression changes that are not associated with changes in the primary nucleotide sequence are referred to as epigenetic changes. This review provides an overview of the regulation of the “epigenome” in neoplastic cells, with particular emphasis on DNA methylation and histone acetylation as therapeutic targets for hematologic malignancies." @default.
- W2337394083 created "2016-06-24" @default.
- W2337394083 creator A5012712111 @default.
- W2337394083 creator A5032464400 @default.
- W2337394083 date "2009-11-01" @default.
- W2337394083 modified "2023-09-25" @default.
- W2337394083 title "Epigenetic Modulation in Hematologic Malignancies: Challenges and Progress" @default.
- W2337394083 cites W107747243 @default.
- W2337394083 cites W1484293540 @default.
- W2337394083 cites W1493846190 @default.
- W2337394083 cites W1497501192 @default.
- W2337394083 cites W1504303645 @default.
- W2337394083 cites W1514748964 @default.
- W2337394083 cites W1533942477 @default.
- W2337394083 cites W1576096421 @default.
- W2337394083 cites W1596185088 @default.
- W2337394083 cites W1658127082 @default.
- W2337394083 cites W1732253485 @default.
- W2337394083 cites W1741394036 @default.
- W2337394083 cites W1774630295 @default.
- W2337394083 cites W1812576394 @default.
- W2337394083 cites W1831451634 @default.
- W2337394083 cites W1963919702 @default.
- W2337394083 cites W1965262464 @default.
- W2337394083 cites W1967018540 @default.
- W2337394083 cites W1968972540 @default.
- W2337394083 cites W1970772467 @default.
- W2337394083 cites W1970827919 @default.
- W2337394083 cites W1971899586 @default.
- W2337394083 cites W1972180057 @default.
- W2337394083 cites W1973707768 @default.
- W2337394083 cites W1974277276 @default.
- W2337394083 cites W1974359182 @default.
- W2337394083 cites W1974747095 @default.
- W2337394083 cites W1976665551 @default.
- W2337394083 cites W1980870391 @default.
- W2337394083 cites W1981745443 @default.
- W2337394083 cites W1982089215 @default.
- W2337394083 cites W1985123079 @default.
- W2337394083 cites W1988085700 @default.
- W2337394083 cites W1989167457 @default.
- W2337394083 cites W1990381590 @default.
- W2337394083 cites W1995049733 @default.
- W2337394083 cites W1995070143 @default.
- W2337394083 cites W1995457775 @default.
- W2337394083 cites W1996358062 @default.
- W2337394083 cites W2001050106 @default.
- W2337394083 cites W2001158436 @default.
- W2337394083 cites W2004172747 @default.
- W2337394083 cites W2009466213 @default.
- W2337394083 cites W2010631526 @default.
- W2337394083 cites W2014286894 @default.
- W2337394083 cites W2015565066 @default.
- W2337394083 cites W2016419012 @default.
- W2337394083 cites W2019163316 @default.
- W2337394083 cites W2019511770 @default.
- W2337394083 cites W2022051395 @default.
- W2337394083 cites W2027741880 @default.
- W2337394083 cites W2029459160 @default.
- W2337394083 cites W2029484950 @default.
- W2337394083 cites W2035588879 @default.
- W2337394083 cites W2036256995 @default.
- W2337394083 cites W2038130483 @default.
- W2337394083 cites W2038581469 @default.
- W2337394083 cites W2040257851 @default.
- W2337394083 cites W2041592237 @default.
- W2337394083 cites W2043358073 @default.
- W2337394083 cites W2043597034 @default.
- W2337394083 cites W2052115456 @default.
- W2337394083 cites W2052169053 @default.
- W2337394083 cites W2052181006 @default.
- W2337394083 cites W2052837845 @default.
- W2337394083 cites W2053747212 @default.
- W2337394083 cites W2059624809 @default.
- W2337394083 cites W2062093164 @default.
- W2337394083 cites W2069584474 @default.
- W2337394083 cites W2070433411 @default.
- W2337394083 cites W2071115015 @default.
- W2337394083 cites W2073033930 @default.
- W2337394083 cites W2076618829 @default.
- W2337394083 cites W2077993954 @default.
- W2337394083 cites W2083189092 @default.
- W2337394083 cites W2084748297 @default.
- W2337394083 cites W2092087093 @default.
- W2337394083 cites W2092586481 @default.
- W2337394083 cites W2094429150 @default.
- W2337394083 cites W2094483021 @default.
- W2337394083 cites W2097220697 @default.
- W2337394083 cites W2098785952 @default.
- W2337394083 cites W2100972878 @default.
- W2337394083 cites W2102606444 @default.
- W2337394083 cites W2103309832 @default.
- W2337394083 cites W2104337841 @default.
- W2337394083 cites W2105100844 @default.
- W2337394083 cites W2106357158 @default.
- W2337394083 cites W2107558077 @default.
- W2337394083 cites W2108691372 @default.
- W2337394083 cites W2108968802 @default.