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• W2337400960 abstract "Abstract Despite decades of research, malaria remains a global health crisis. Current subunit vaccine approaches do not provide efficient long-term, sterilizing immunity against Plasmodium infections in humans. Conversely, whole parasite vaccinations with their larger array of target Ags have conferred long-lasting sterilizing protection to humans. Similar studies in rodent models of malaria reveal that CD8+ T cells play a critical role in liver-stage immunity after whole parasite vaccination. However, it is unknown whether all CD8+ T cell specificities elicited by whole parasite vaccination contribute to protection, an issue of great relevance for enhanced subunit vaccination. In this article, we show that robust CD8+ T cell responses of similar phenotype are mounted after prime-boost immunization against Plasmodium berghei glideosome-associated protein 5041–48–, sporozoite-specific protein 20318–325–, thrombospondin-related adhesion protein (TRAP) 130–138-, or circumsporozoite protein (CSP) 252–260-derived epitopes in mice, but only CSP252–260- and TRAP130–138-specific CD8+ T cells provide sterilizing immunity and reduce liver parasite burden after sporozoite challenge. Further, CD8+ T cells specific to sporozoite surface-expressed CSP and TRAP proteins, but not intracellular glideosome-associated protein 50 and sporozoite-specific protein 20, efficiently recognize sporozoite-infected hepatocytes in vitro. These results suggest that: 1) protection-relevant antigenic targets, regardless of their immunogenic potential, must be efficiently presented by infected hepatocytes for CD8+ T cells to eliminate liver-stage Plasmodium infection; and 2) proteins expressed on the surface of sporozoites may be good target Ags for protective CD8+ T cells." @default.
• W2337400960 created "2016-06-24" @default.
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• W2337400960 date "2016-05-15" @default.
• W2337400960 modified "2023-10-03" @default.
• W2337400960 title "Discriminating Protective from Nonprotective <i>Plasmodium</i>-Specific CD8+ T Cell Responses" @default.
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• W2337400960 doi "https://doi.org/10.4049/jimmunol.1600155" @default.
• W2337400960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4868661" @default.
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