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- W2337451439 abstract "In chronic myelogenous leukemia (CML) the Philadelphia (Ph) chromosome originates from a reciprocal translocation, t(9;22)(q34;q11),1 that generates a chimeric BCR-ABL gene.2 The disease is incurable without bone marrow transplantation. In some cases, intensive chemotherapy3,4 or treatment with interferon alfa can suppress the Ph-positive clone in the bone marrow,5–7 but the detection of residual disease by the polymerase chain reaction (PCR) in patients with a complete cytogenetic response suggests incomplete eradication of these cells.8 Few cases of Ph-positive CML have been reported in which a long-term remission occurred without treatment.9–11 We describe a patient with Ph-positive CML who . . ." @default.
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- W2337451439 date "1997-01-30" @default.
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- W2337451439 title "Spontaneous Remission in a Patient with Chronic Myelogenous Leukemia" @default.
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- W2337451439 doi "https://doi.org/10.1056/nejm199701303360504" @default.
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