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- W2337472569 abstract "In patients with disseminated intravascular coagulation, decreased plasma factor XII has been observed in several occasions (1). Activation of plasma factor XII, Hageman factor, induced kinin formation but the role played by the kinin system in the vascular changes following intravascular coagulation is till now ill defined. Ratnoff and Crum (2) have demonstrated that the activation of Hageman factor can be elicited with solutions of ellagic acid (EA). However, “in vivo”, small doses of EA have been often used and no intravascular coagulation has been observed following EA injection (3, 4, 5, 6). To look for the involvement of the kinin system in the vascular changes resulting from intravascular coagulation induced by Hageman factor activation, we have thus compared the effects of very large doses of EA in normal rats and in kininogen-deficient Brown Norway rats (7, 8, 9)." @default.
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- W2337472569 date "1989-01-01" @default.
- W2337472569 modified "2023-09-27" @default.
- W2337472569 title "Some Cardiovascular and Hematological Changes Induced in the Rat by Activation of Hageman Factor with Ellagic Acid" @default.
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- W2337472569 doi "https://doi.org/10.1007/978-1-4615-9543-4_70" @default.
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