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- W2337480304 abstract "Several mechanisms that utilize farnesyl pyro- phosphate and nerolidyl pyrophosphate as condensing sub- strates have been postulated for the asymmetric condensation reaction in squalene biosynthesis. Although there is ample evi- dence that farnesyl pyrophosphate is a substrate for this reac- tion, there has been no information concerning the role of nerolidyl pyrophosphate. We have made the following observa- tions that demonstrate that nerolidyl pyrophosphate cannot be a free intermediate in squalene biosynthesis. (a) There is no significant interconversion of farnesyl pyrophosphate and nero- lidyl pyrophosphate in a squalene-synthesizing system from yeast. (b) Ner~lidyI-l-~H~ pyrophosphate is not converted to squalene in the presence or absence of farnesyl pyrophosphate. (c) The addition of unlabeled nerolidyl pyrophosphate to incu- bation mixtures does not alter the relative loss of a-hydrogens from farnesyl pyrophosphate during its conversion to squalene. The synthesis of ner~lidyl-l-~Hz pyrophosphate is described. Chromatographic methods for the separation of pyrophosphate esters of triprenols and terpenols are included." @default.
- W2337480304 created "2016-06-24" @default.
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- W2337480304 date "1969-03-01" @default.
- W2337480304 modified "2023-09-29" @default.
- W2337480304 title "Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate" @default.
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- W2337480304 doi "https://doi.org/10.1016/s0022-2275(20)42666-5" @default.
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