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- W2337501691 abstract "Introduction Since the association between kidney disease and anaemia was first described in 1836 /1/, a reduced red cell mass has been considered a characteristic feature of chronic renal failure (CRF). In paediatric patients with CRF a linear relationship between glomerular filtration rate (GFR) and hematocrit (Hct) has been observed /2,3/. Inadequate erythropoietin production is one of the main causes of renal anaemia. Other causes are: reduced red blood cell lifespan, chronic blood loss, iron deficiency, inhibitors of erythropoiesis and malnutrition. The advent of recombinant human erythopoietin therapy (rHuEPO) in 1986 /4,5/ revolutionized the treatment of anaemia in CRF. While rHuEPO is effective in the correction of anaemia in most cases, there is a significant number of patients who fail to respond, and there is an extremely low number of those who get pure red cell aplasia (PRCA) during rHuEPO therapy /6/. The optimisation of rhEPO therapy includes the awareness of target Hct and Hb, defining the renal anaemia management period, drug dosage and mode of its application, and the significance of adjuvant therapy. This paper discusses optimal modes of anaemia management in children with CRF." @default.
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- W2337501691 date "2003-01-01" @default.
- W2337501691 modified "2023-09-28" @default.
- W2337501691 title "Anaemia Management of Children with Chronic Renal Failure" @default.
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