FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337502608> ?p ?o ?g. }

• W2337502608 abstract "Event Abstract Back to Event Dual-sensitive hydrogel composite for local release and selective uptake of chemotherapy for the treatment of breast cancer Yi Zhang1, Joao Conde1, 2, Nuria Oliva1 and Natalie Artzi1, 3 1 Massachusetts institute of technology, Institute of Medical Engineering and Science, United States 2 Queen Mary University of London, School of Engineering and Materials Science, United Kingdom 3 Harvard Medical School, Department of Anesthesiology, United States Introduction: The use of drug delivery device, in particular biodegradable polymeric materials, has generated a huge scientific and economic impact on cancer treatment. Ideally, cancer-treatment should encompass selective delivery of therapeutics to the tumor site in a sustained manner, and rapidly kill cancer cells after their uptake. However, neither hydrogel nor nanoparticles, the two most commonly used drug delivery devices, are capable of fulfilling these requirements alone. Herein, we developed a pH and redox dual-sensitive composite hydrogel that selectively delivers chemotherapy to triple negative breast cancer cells in a sustained manner. The drug is only being released while in the cell and efficiently eradicates the tumor. Materials and Methods: Dual-sensitive nanogels were composed of dextran and cystamine. Hydrogels were fabricated by crosslinking Dextran and G5 Dendrimer. Doxorubicin release rate from both nanogels and composite hydrogels were evaluated. RGD has been conjugated onto nanogels to improve selectivity to cancer cells, which were characterized by in vitro cell culture. Treatment efficacy of biosensitive composite hydrogels was evaluated using mice with orthotopic triple negative breast cancer. Results and Discussion: The composite hydrogel composed of dual-sensitive Dextran nanogels embedded in Dextran:Dendrimer hydrogel (Fig 1A). Dextran was oxidized and formed prodrug with Doxorubicin, confirmed by 1H-NMR. In vitro drug release study showed that releasing rate differs under various pH and redox solution (Fig. 1B). The local and controlled drug release rate was enabled by pro-drug formation and protection of the particles by their embedding in the hydrogel. This was then followed by a rapid drug release when inside the cancer cells afforded by fast degradation of the nanogels under the acidic and reductive environment in the cell. The dual-sensitive nanogels have high selectivity towards cancer cells only as evidenced by confocal images and flow cytometry assays and show rapid therapeutic effect when applied in vitro to cancer cells with no effect on healthy cells (Fig 1C, D). The biosensitive composite hydrogels provide sustained and selective release in vivo for up to 11d enabling high tumor shrinkage compared to systemic administration of dual sensitive nanogels and non-sensitive composite hydrogels (Fig 2). The promising results of the in vivo animal studies demonstrate that the dual-sensitive composite hydrogels provides a successful approach for breast cancer treatment. Conclusion: We exploited the tumor-targeting peptide to enable selective chemotherapy uptake to cancer cells while sparing healthy cells. Local delivery of drug enabled sustained release, uptake and then fast release while inside the cancer cell through both pH and redox-triggered release. This dual-sensitive device can be exploited to deliver many types of anti-cancer therapeutics to treat the tumor of interests. The success of the presented biosensitive composite hydrogels may present a paradigm shift in designing cancer-treating device. Keywords: Hydrogel, Drug delivery, stimuli-response, targeting delivery Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: General Session Oral Topic: Biomaterials for cancer therapy Citation: Zhang Y, Conde J, Oliva N and Artzi N (2016). Dual-sensitive hydrogel composite for local release and selective uptake of chemotherapy for the treatment of breast cancer. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01331 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Yi Zhang Joao Conde Nuria Oliva Natalie Artzi Google Yi Zhang Joao Conde Nuria Oliva Natalie Artzi Google Scholar Yi Zhang Joao Conde Nuria Oliva Natalie Artzi PubMed Yi Zhang Joao Conde Nuria Oliva Natalie Artzi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
• W2337502608 created "2016-06-24" @default.
• W2337502608 creator A5019148940 @default.
• W2337502608 creator A5047043019 @default.
• W2337502608 creator A5047066324 @default.
• W2337502608 creator A5058199128 @default.
• W2337502608 date "2016-01-01" @default.
• W2337502608 modified "2023-09-27" @default.
• W2337502608 title "Dual-sensitive hydrogel composite for local release and selective uptake of chemotherapy for the treatment of breast cancer" @default.
• W2337502608 doi "https://doi.org/10.3389/conf.fbioe.2016.01.01331" @default.
• W2337502608 hasPublicationYear "2016" @default.
• W2337502608 type Work @default.
• W2337502608 sameAs 2337502608 @default.
• W2337502608 citedByCount "1" @default.
• W2337502608 countsByYear W23375026082022 @default.
• W2337502608 crossrefType "journal-article" @default.
• W2337502608 hasAuthorship W2337502608A5019148940 @default.
• W2337502608 hasAuthorship W2337502608A5047043019 @default.
• W2337502608 hasAuthorship W2337502608A5047066324 @default.
• W2337502608 hasAuthorship W2337502608A5058199128 @default.
• W2337502608 hasBestOaLocation W23375026081 @default.
• W2337502608 hasConcept C108586683 @default.
• W2337502608 hasConcept C121608353 @default.
• W2337502608 hasConcept C126322002 @default.
• W2337502608 hasConcept C136229726 @default.
• W2337502608 hasConcept C171250308 @default.
• W2337502608 hasConcept C185592680 @default.
• W2337502608 hasConcept C188027245 @default.
• W2337502608 hasConcept C192562407 @default.
• W2337502608 hasConcept C2776694085 @default.
• W2337502608 hasConcept C2779820397 @default.
• W2337502608 hasConcept C2780110267 @default.
• W2337502608 hasConcept C2781303535 @default.
• W2337502608 hasConcept C502942594 @default.
• W2337502608 hasConcept C530470458 @default.
• W2337502608 hasConcept C71924100 @default.
• W2337502608 hasConcept C96232424 @default.
• W2337502608 hasConcept C98274493 @default.
• W2337502608 hasConceptScore W2337502608C108586683 @default.
• W2337502608 hasConceptScore W2337502608C121608353 @default.
• W2337502608 hasConceptScore W2337502608C126322002 @default.
• W2337502608 hasConceptScore W2337502608C136229726 @default.
• W2337502608 hasConceptScore W2337502608C171250308 @default.
• W2337502608 hasConceptScore W2337502608C185592680 @default.
• W2337502608 hasConceptScore W2337502608C188027245 @default.
• W2337502608 hasConceptScore W2337502608C192562407 @default.
• W2337502608 hasConceptScore W2337502608C2776694085 @default.
• W2337502608 hasConceptScore W2337502608C2779820397 @default.
• W2337502608 hasConceptScore W2337502608C2780110267 @default.
• W2337502608 hasConceptScore W2337502608C2781303535 @default.
• W2337502608 hasConceptScore W2337502608C502942594 @default.
• W2337502608 hasConceptScore W2337502608C530470458 @default.
• W2337502608 hasConceptScore W2337502608C71924100 @default.
• W2337502608 hasConceptScore W2337502608C96232424 @default.
• W2337502608 hasConceptScore W2337502608C98274493 @default.
• W2337502608 hasLocation W23375026081 @default.
• W2337502608 hasOpenAccess W2337502608 @default.
• W2337502608 hasPrimaryLocation W23375026081 @default.
• W2337502608 hasRelatedWork W2062374771 @default.
• W2337502608 hasRelatedWork W2256572352 @default.
• W2337502608 hasRelatedWork W2368558437 @default.
• W2337502608 hasRelatedWork W2537171611 @default.
• W2337502608 hasRelatedWork W2899084033 @default.
• W2337502608 hasRelatedWork W2982063350 @default.
• W2337502608 hasRelatedWork W3104662334 @default.
• W2337502608 hasRelatedWork W4322502629 @default.
• W2337502608 hasRelatedWork W4378417641 @default.
• W2337502608 hasRelatedWork W4383819681 @default.
• W2337502608 hasVolume "4" @default.
• W2337502608 isParatext "false" @default.
• W2337502608 isRetracted "false" @default.
• W2337502608 magId "2337502608" @default.
• W2337502608 workType "article" @default.