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• W2337514298 abstract "Preparation of small molecule based dual-modality probes remains a challenging task due to the complicated synthetic procedure. In this study, a novel concise and generic strategy for preparing dual-modality optical/PET imaging probes via photo-click chemistry was developed, in which the diazole photo-click linker functioned not only as a bridge between the targeting-ligand and the PET imaging moiety, but also as the fluorophore for optical imaging. A dual-modality AE105 peptidic probe was successfully generated via this strategy and subsequently applied in the fluorescent staining of U87MG cells and the 68Ga based PET imaging of mice bearing U87MG xenograft. In addition, dual-modality monoclonal antibody cetuximab has also been generated via this strategy and labeled with 64Cu for PET imaging studies, broadening the application of this strategy to include the preparation of macromolecule based imaging probes." @default.
• W2337514298 created "2016-06-24" @default.
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• W2337514298 date "2016-04-27" @default.
• W2337514298 modified "2023-10-16" @default.
• W2337514298 title "Novel Strategy for Preparing Dual-Modality Optical/PET Imaging Probes via Photo-Click Chemistry" @default.
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• W2337514298 doi "https://doi.org/10.1021/acs.bioconjchem.6b00115" @default.
• W2337514298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4871752" @default.
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