Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337578172> ?p ?o ?g. }
- W2337578172 endingPage "20" @default.
- W2337578172 startingPage "15" @default.
- W2337578172 abstract "Cisplatin is a potent chemotherapeutic agent for the treatment of various solid-organ cancers. However, a plethora of evidence indicates that nephrotoxicity is a major side effect of cisplatin therapy. While the antineoplastic action of cisplatin is due to formation of cisplatin-DNA cross-links, which damage rapidly dividing cancer cells upon binding to DNA, its nephrotoxic effect results from metabolic conversion of cisplatin into a nephrotoxin and production of reactive oxygen species, causing oxidative stress leading to renal tissue injury and potentially, kidney failure. Despite therapeutic targets in several pre-clinical and clinical studies, there is still incomplete protection against cisplatin-induced nephrotoxicity. Hydrogen sulfide (H2S), the third discovered gasotransmitter next to nitric oxide and carbon monoxide, has recently been identified in several in vitro and in vivo studies to possess specific antioxidant, anti-inflammatory and anti-apoptotic properties that modulate several pathogenic pathways involved in cisplatin-induced nephrotoxicity. The current article reviews the molecular mechanisms underlying cisplatin-induced nephrotoxicity and displays recent findings in the H2S field that could disrupt such mechanisms to ameliorate cisplatin-induced renal injury." @default.
- W2337578172 created "2016-06-24" @default.
- W2337578172 creator A5028010297 @default.
- W2337578172 creator A5078207248 @default.
- W2337578172 creator A5079070757 @default.
- W2337578172 creator A5080843508 @default.
- W2337578172 date "2016-07-01" @default.
- W2337578172 modified "2023-10-16" @default.
- W2337578172 title "Hydrogen sulfide: A novel nephroprotectant against cisplatin-induced renal toxicity" @default.
- W2337578172 cites W1541015815 @default.
- W2337578172 cites W1741860215 @default.
- W2337578172 cites W1868039889 @default.
- W2337578172 cites W1964722626 @default.
- W2337578172 cites W1967680969 @default.
- W2337578172 cites W1971483431 @default.
- W2337578172 cites W1971492805 @default.
- W2337578172 cites W1974836020 @default.
- W2337578172 cites W1980411311 @default.
- W2337578172 cites W1982768697 @default.
- W2337578172 cites W1982895791 @default.
- W2337578172 cites W1984045639 @default.
- W2337578172 cites W1995041486 @default.
- W2337578172 cites W2011928019 @default.
- W2337578172 cites W2012108057 @default.
- W2337578172 cites W2012910608 @default.
- W2337578172 cites W2013903273 @default.
- W2337578172 cites W2018192442 @default.
- W2337578172 cites W2028516053 @default.
- W2337578172 cites W2032086569 @default.
- W2337578172 cites W2038600558 @default.
- W2337578172 cites W2044281473 @default.
- W2337578172 cites W2052544801 @default.
- W2337578172 cites W2062289724 @default.
- W2337578172 cites W2082194448 @default.
- W2337578172 cites W2083996210 @default.
- W2337578172 cites W2085177403 @default.
- W2337578172 cites W2099115268 @default.
- W2337578172 cites W2114213164 @default.
- W2337578172 cites W2114966729 @default.
- W2337578172 cites W2127552400 @default.
- W2337578172 cites W2127618819 @default.
- W2337578172 cites W2131545170 @default.
- W2337578172 cites W2132290398 @default.
- W2337578172 cites W2132508967 @default.
- W2337578172 cites W2139322211 @default.
- W2337578172 cites W2141610173 @default.
- W2337578172 cites W2147804877 @default.
- W2337578172 cites W2164277862 @default.
- W2337578172 cites W2164391817 @default.
- W2337578172 cites W2168545028 @default.
- W2337578172 cites W2252858072 @default.
- W2337578172 cites W2297765303 @default.
- W2337578172 cites W4240717991 @default.
- W2337578172 doi "https://doi.org/10.1016/j.niox.2016.04.005" @default.
- W2337578172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27095538" @default.
- W2337578172 hasPublicationYear "2016" @default.
- W2337578172 type Work @default.
- W2337578172 sameAs 2337578172 @default.
- W2337578172 citedByCount "32" @default.
- W2337578172 countsByYear W23375781722016 @default.
- W2337578172 countsByYear W23375781722017 @default.
- W2337578172 countsByYear W23375781722018 @default.
- W2337578172 countsByYear W23375781722019 @default.
- W2337578172 countsByYear W23375781722020 @default.
- W2337578172 countsByYear W23375781722021 @default.
- W2337578172 countsByYear W23375781722022 @default.
- W2337578172 countsByYear W23375781722023 @default.
- W2337578172 crossrefType "journal-article" @default.
- W2337578172 hasAuthorship W2337578172A5028010297 @default.
- W2337578172 hasAuthorship W2337578172A5078207248 @default.
- W2337578172 hasAuthorship W2337578172A5079070757 @default.
- W2337578172 hasAuthorship W2337578172A5080843508 @default.
- W2337578172 hasConcept C126189478 @default.
- W2337578172 hasConcept C126322002 @default.
- W2337578172 hasConcept C143425029 @default.
- W2337578172 hasConcept C150903083 @default.
- W2337578172 hasConcept C178790620 @default.
- W2337578172 hasConcept C185592680 @default.
- W2337578172 hasConcept C207001950 @default.
- W2337578172 hasConcept C2776151105 @default.
- W2337578172 hasConcept C2776694085 @default.
- W2337578172 hasConcept C2778239845 @default.
- W2337578172 hasConcept C2780472472 @default.
- W2337578172 hasConcept C29730261 @default.
- W2337578172 hasConcept C48349386 @default.
- W2337578172 hasConcept C502942594 @default.
- W2337578172 hasConcept C519581460 @default.
- W2337578172 hasConcept C552990157 @default.
- W2337578172 hasConcept C55493867 @default.
- W2337578172 hasConcept C71924100 @default.
- W2337578172 hasConcept C86803240 @default.
- W2337578172 hasConcept C98274493 @default.
- W2337578172 hasConceptScore W2337578172C126189478 @default.
- W2337578172 hasConceptScore W2337578172C126322002 @default.
- W2337578172 hasConceptScore W2337578172C143425029 @default.
- W2337578172 hasConceptScore W2337578172C150903083 @default.
- W2337578172 hasConceptScore W2337578172C178790620 @default.
- W2337578172 hasConceptScore W2337578172C185592680 @default.