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• W2337604611 endingPage "221" @default.
• W2337604611 startingPage "213" @default.
• W2337604611 abstract "Opioid antagonists (eg, naltrexone) and positive modulators of γ-aminobutyric acid type A receptors (eg, alprazolam) each modestly attenuate the abuse-related effects of stimulants. A previous study demonstrated that acute pretreatment with the combination of naltrexone and alprazolam attenuated a greater number of the subject-rated effects of D-amphetamine than the constituent drugs alone. This study tested the hypothesis that maintenance on the combination of naltrexone and alprazolam XR would attenuate the reinforcing and positive subject-rated effects of methamphetamine to a greater extent than the constituent drugs alone.Eight non-treatment-seeking, stimulant-using individuals completed a placebo-controlled, crossover, double-blind inpatient protocol. Participants were maintained on naltrexone (0 and 50 mg), alprazolam XR (0 and 1 mg), and the combination of naltrexone and alprazolam XR (50 mg and 1 mg, respectively) for 6 to 7 days. Under each maintenance condition, participants sampled intranasal doses of methamphetamine (0, 10, and 30 mg), and were then offered the opportunity to work for the sampled dose on a modified progressive-ratio procedure. Subject-rated drug effect questionnaires, psychomotor, and physiology assessments were collected.Intranasal methamphetamine functioned as a reinforcer and produced prototypical stimulant-like positive subject-rated and physiological effects. Maintenance on naltrexone significantly decreased the reinforcing, but not subject-rated drug effects of 10-mg methamphetamine. Alprazolam XR and the combination of naltrexone and alprazolam XR did not impact methamphetamine self-administration or subject-rated drug effects. The results support the continued evaluation of naltrexone for methamphetamine dependence, as well as the identification of other drugs that enhance its ability to reduce drug-taking behavior." @default.
• W2337604611 created "2016-06-24" @default.
• W2337604611 creator A5001197181 @default.
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• W2337604611 date "2016-06-01" @default.
• W2337604611 modified "2023-09-25" @default.
• W2337604611 title "Separate and Combined Effects of Naltrexone and Extended-Release Alprazolam on the Reinforcing, Subject-Rated, and Cardiovascular Effects of Methamphetamine" @default.
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• W2337604611 cites W1747110054 @default.
• W2337604611 cites W1895388428 @default.
• W2337604611 cites W1950497346 @default.
• W2337604611 cites W1964170525 @default.
• W2337604611 cites W1965182972 @default.
• W2337604611 cites W1965528317 @default.
• W2337604611 cites W1967025712 @default.
• W2337604611 cites W1968503585 @default.
• W2337604611 cites W1970373428 @default.
• W2337604611 cites W1972244997 @default.
• W2337604611 cites W1972873401 @default.
• W2337604611 cites W1974201997 @default.
• W2337604611 cites W1976857986 @default.
• W2337604611 cites W1978196659 @default.
• W2337604611 cites W1979573315 @default.
• W2337604611 cites W1980046175 @default.
• W2337604611 cites W1985100821 @default.
• W2337604611 cites W1991144409 @default.
• W2337604611 cites W1992179844 @default.
• W2337604611 cites W1998674360 @default.
• W2337604611 cites W1999458463 @default.
• W2337604611 cites W2002420302 @default.
• W2337604611 cites W2002827980 @default.
• W2337604611 cites W2005781055 @default.
• W2337604611 cites W2007139480 @default.
• W2337604611 cites W2008032124 @default.
• W2337604611 cites W2010129571 @default.
• W2337604611 cites W2011100195 @default.
• W2337604611 cites W2011181517 @default.
• W2337604611 cites W2023643911 @default.
• W2337604611 cites W2031064091 @default.
• W2337604611 cites W2035103509 @default.
• W2337604611 cites W2035343906 @default.
• W2337604611 cites W2038898066 @default.
• W2337604611 cites W2040116927 @default.
• W2337604611 cites W2046083750 @default.
• W2337604611 cites W2046579689 @default.
• W2337604611 cites W2047501424 @default.
• W2337604611 cites W2054984124 @default.
• W2337604611 cites W2056274039 @default.
• W2337604611 cites W2058038425 @default.
• W2337604611 cites W2060475215 @default.
• W2337604611 cites W2065733295 @default.
• W2337604611 cites W2068584155 @default.
• W2337604611 cites W2069089369 @default.
• W2337604611 cites W2074429989 @default.
• W2337604611 cites W2086573094 @default.
• W2337604611 cites W2090627492 @default.
• W2337604611 cites W2094206436 @default.
• W2337604611 cites W2095384014 @default.
• W2337604611 cites W2098644261 @default.
• W2337604611 cites W2105829233 @default.
• W2337604611 cites W2109159740 @default.
• W2337604611 cites W2111112265 @default.
• W2337604611 cites W2111308956 @default.
• W2337604611 cites W2116763568 @default.
• W2337604611 cites W2120219218 @default.
• W2337604611 cites W2141225113 @default.
• W2337604611 cites W2146196757 @default.
• W2337604611 cites W2164740960 @default.
• W2337604611 cites W2168427659 @default.
• W2337604611 cites W2223273811 @default.
• W2337604611 cites W2261901423 @default.
• W2337604611 cites W2321872756 @default.
• W2337604611 cites W2323042322 @default.
• W2337604611 cites W2415963871 @default.
• W2337604611 cites W4235076757 @default.
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• W2337604611 doi "https://doi.org/10.1097/jcp.0000000000000488" @default.
• W2337604611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4837068" @default.
• W2337604611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27043121" @default.
• W2337604611 hasPublicationYear "2016" @default.
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