Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337621805> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2337621805 abstract "Targeted nucleotide exchange (TNE) relies on the use of a short synthetic oligonucleotide (ODN) designed to be complementary to a target sequence in the genome except for a centrally located mismatch, which directs the desired base change in the DNA. The repair reaction is believed to be enhanced by mechanisms that promote a more open conformation of the DNA, thus, enabling the target site to be more accessible for the binding of the oligonucleotide. One such method is through the modulation of cell cycle progression to increase the population of cells in S phase, wherein targeting of a single base pair is enhanced. Studies aimed at demonstrating the variations in correction in relation to cell cycle measured repair frequency late in the reaction cycle. Our work aims to discern variations in repair levels in subphases of S as cells enter and progress through this phase, in the presence of the oligonucleotide. In addition, we evaluate gene expression patterns of several cell cycle genes that may help denote the changes in cell cycle distribution as a function of gene repair events. Additional research has been performed analyzing gene expression patterns in malignant versus non-malignant esophageal cancer cells in response to treatment with G-rich oligonucleotides (GRO). It has been shown that these single-stranded DNA molecules which are comprised primarily of guanosine residues induce retardation in the progression of the cell cycle, and result in a sub-G1 population of apoptotic cells. Successful inhibition of growth of malignant, but not nonmalignant, cells has been seen. Thus, G-rich ODNs may be guiding the selective killing of tumor cells. I am currently analyzing the RNA levels of apoptosis genes incubated with GROs to understand how the cells are responding, and which pathway may be responsible for the induction of apoptosis. Funded by Howard Hughes Medical Institute." @default.
- W2337621805 created "2016-06-24" @default.
- W2337621805 creator A5043822846 @default.
- W2337621805 creator A5059383666 @default.
- W2337621805 creator A5081138565 @default.
- W2337621805 creator A5087169060 @default.
- W2337621805 date "2008-03-01" @default.
- W2337621805 modified "2023-09-27" @default.
- W2337621805 title "Gene Repair in sub‐S phase Cell Populations and Cell Cycle Response to Quadruplex Oligonucleotides" @default.
- W2337621805 doi "https://doi.org/10.1096/fasebj.22.1_supplement.648.10" @default.
- W2337621805 hasPublicationYear "2008" @default.
- W2337621805 type Work @default.
- W2337621805 sameAs 2337621805 @default.
- W2337621805 citedByCount "0" @default.
- W2337621805 crossrefType "journal-article" @default.
- W2337621805 hasAuthorship W2337621805A5043822846 @default.
- W2337621805 hasAuthorship W2337621805A5059383666 @default.
- W2337621805 hasAuthorship W2337621805A5081138565 @default.
- W2337621805 hasAuthorship W2337621805A5087169060 @default.
- W2337621805 hasConcept C104317684 @default.
- W2337621805 hasConcept C105696609 @default.
- W2337621805 hasConcept C129312508 @default.
- W2337621805 hasConcept C134935766 @default.
- W2337621805 hasConcept C1491633281 @default.
- W2337621805 hasConcept C150194340 @default.
- W2337621805 hasConcept C153911025 @default.
- W2337621805 hasConcept C2777995097 @default.
- W2337621805 hasConcept C2908647359 @default.
- W2337621805 hasConcept C29537977 @default.
- W2337621805 hasConcept C54355233 @default.
- W2337621805 hasConcept C552990157 @default.
- W2337621805 hasConcept C71924100 @default.
- W2337621805 hasConcept C86803240 @default.
- W2337621805 hasConcept C95444343 @default.
- W2337621805 hasConcept C99454951 @default.
- W2337621805 hasConceptScore W2337621805C104317684 @default.
- W2337621805 hasConceptScore W2337621805C105696609 @default.
- W2337621805 hasConceptScore W2337621805C129312508 @default.
- W2337621805 hasConceptScore W2337621805C134935766 @default.
- W2337621805 hasConceptScore W2337621805C1491633281 @default.
- W2337621805 hasConceptScore W2337621805C150194340 @default.
- W2337621805 hasConceptScore W2337621805C153911025 @default.
- W2337621805 hasConceptScore W2337621805C2777995097 @default.
- W2337621805 hasConceptScore W2337621805C2908647359 @default.
- W2337621805 hasConceptScore W2337621805C29537977 @default.
- W2337621805 hasConceptScore W2337621805C54355233 @default.
- W2337621805 hasConceptScore W2337621805C552990157 @default.
- W2337621805 hasConceptScore W2337621805C71924100 @default.
- W2337621805 hasConceptScore W2337621805C86803240 @default.
- W2337621805 hasConceptScore W2337621805C95444343 @default.
- W2337621805 hasConceptScore W2337621805C99454951 @default.
- W2337621805 hasFunder F4320306082 @default.
- W2337621805 hasIssue "S1" @default.
- W2337621805 hasLocation W23376218051 @default.
- W2337621805 hasOpenAccess W2337621805 @default.
- W2337621805 hasPrimaryLocation W23376218051 @default.
- W2337621805 hasRelatedWork W1544463062 @default.
- W2337621805 hasRelatedWork W1903281146 @default.
- W2337621805 hasRelatedWork W2009966535 @default.
- W2337621805 hasRelatedWork W2091721403 @default.
- W2337621805 hasRelatedWork W2116193195 @default.
- W2337621805 hasRelatedWork W2144284013 @default.
- W2337621805 hasRelatedWork W2415398623 @default.
- W2337621805 hasRelatedWork W2810121841 @default.
- W2337621805 hasRelatedWork W3130179865 @default.
- W2337621805 hasRelatedWork W4280493527 @default.
- W2337621805 hasVolume "22" @default.
- W2337621805 isParatext "false" @default.
- W2337621805 isRetracted "false" @default.
- W2337621805 magId "2337621805" @default.
- W2337621805 workType "article" @default.