FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337632357> ?p ?o ?g. }

• W2337632357 abstract "We previously established a mechanism of negative regulation of transforming growth factor β signaling mediated by the nuclear ADP-ribosylating enzyme poly-(ADP-ribose) polymerase 1 (PARP1) and the deribosylating enzyme poly-(ADP-ribose) glycohydrolase (PARG), which dynamically regulate ADP-ribosylation of Smad3 and Smad4, two central signaling proteins of the pathway. Here we demonstrate that the bone morphogenetic protein (BMP) pathway can also be regulated by the opposing actions of PARP1 and PARG. PARG positively contributes to BMP signaling and forms physical complexes with Smad5 and Smad4. The positive role PARG plays during BMP signaling can be neutralized by PARP1, as demonstrated by experiments where PARG and PARP1 are simultaneously silenced. In contrast to PARG, ectopic expression of PARP1 suppresses BMP signaling, whereas silencing of endogenous PARP1 enhances signaling and BMP-induced differentiation. The two major Smad proteins of the BMP pathway, Smad1 and Smad5, interact with PARP1 and can be ADP-ribosylated in vitro, whereas PARG causes deribosylation. The overall outcome of this mode of regulation of BMP signal transduction provides a fine-tuning mechanism based on the two major enzymes that control cellular ADP-ribosylation." @default.
• W2337632357 created "2016-06-24" @default.
• W2337632357 creator A5000466584 @default.
• W2337632357 creator A5020551415 @default.
• W2337632357 creator A5046176669 @default.
• W2337632357 creator A5069280887 @default.
• W2337632357 creator A5072088923 @default.
• W2337632357 creator A5075463711 @default.
• W2337632357 creator A5084535456 @default.
• W2337632357 date "2016-06-01" @default.
• W2337632357 modified "2023-10-17" @default.
• W2337632357 title "Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation" @default.
• W2337632357 cites W1582760249 @default.
• W2337632357 cites W1935346479 @default.
• W2337632357 cites W1963767618 @default.
• W2337632357 cites W1970098795 @default.
• W2337632357 cites W1979048165 @default.
• W2337632357 cites W1992397774 @default.
• W2337632357 cites W1992496728 @default.
• W2337632357 cites W1994744137 @default.
• W2337632357 cites W2003083523 @default.
• W2337632357 cites W2005271745 @default.
• W2337632357 cites W2009899606 @default.
• W2337632357 cites W2020639312 @default.
• W2337632357 cites W2026409525 @default.
• W2337632357 cites W2037440777 @default.
• W2337632357 cites W2039404256 @default.
• W2337632357 cites W2071970475 @default.
• W2337632357 cites W2072528578 @default.
• W2337632357 cites W2072709416 @default.
• W2337632357 cites W2077239497 @default.
• W2337632357 cites W2079268771 @default.
• W2337632357 cites W2079619073 @default.
• W2337632357 cites W2082732798 @default.
• W2337632357 cites W2085543001 @default.
• W2337632357 cites W2088875346 @default.
• W2337632357 cites W2104174165 @default.
• W2337632357 cites W2112903125 @default.
• W2337632357 cites W2118245574 @default.
• W2337632357 cites W2118385896 @default.
• W2337632357 cites W2141860100 @default.
• W2337632357 cites W2151349025 @default.
• W2337632357 cites W2160073632 @default.
• W2337632357 cites W2166920557 @default.
• W2337632357 doi "https://doi.org/10.1074/jbc.m116.729699" @default.
• W2337632357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4933475" @default.
• W2337632357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27129221" @default.
• W2337632357 hasPublicationYear "2016" @default.
• W2337632357 type Work @default.
• W2337632357 sameAs 2337632357 @default.
• W2337632357 citedByCount "5" @default.
• W2337632357 countsByYear W23376323572016 @default.
• W2337632357 countsByYear W23376323572017 @default.
• W2337632357 countsByYear W23376323572018 @default.
• W2337632357 countsByYear W23376323572020 @default.
• W2337632357 countsByYear W23376323572021 @default.
• W2337632357 crossrefType "journal-article" @default.
• W2337632357 hasAuthorship W2337632357A5000466584 @default.
• W2337632357 hasAuthorship W2337632357A5020551415 @default.
• W2337632357 hasAuthorship W2337632357A5046176669 @default.
• W2337632357 hasAuthorship W2337632357A5069280887 @default.
• W2337632357 hasAuthorship W2337632357A5072088923 @default.
• W2337632357 hasAuthorship W2337632357A5075463711 @default.
• W2337632357 hasAuthorship W2337632357A5084535456 @default.
• W2337632357 hasBestOaLocation W23376323571 @default.
• W2337632357 hasConcept C104317684 @default.
• W2337632357 hasConcept C119056186 @default.
• W2337632357 hasConcept C181199279 @default.
• W2337632357 hasConcept C182979987 @default.
• W2337632357 hasConcept C185592680 @default.
• W2337632357 hasConcept C2778480876 @default.
• W2337632357 hasConcept C2781080636 @default.
• W2337632357 hasConcept C31507581 @default.
• W2337632357 hasConcept C45510557 @default.
• W2337632357 hasConcept C55493867 @default.
• W2337632357 hasConcept C62478195 @default.
• W2337632357 hasConcept C73834784 @default.
• W2337632357 hasConcept C75520062 @default.
• W2337632357 hasConcept C82381507 @default.
• W2337632357 hasConcept C86803240 @default.
• W2337632357 hasConcept C95444343 @default.
• W2337632357 hasConceptScore W2337632357C104317684 @default.
• W2337632357 hasConceptScore W2337632357C119056186 @default.
• W2337632357 hasConceptScore W2337632357C181199279 @default.
• W2337632357 hasConceptScore W2337632357C182979987 @default.
• W2337632357 hasConceptScore W2337632357C185592680 @default.
• W2337632357 hasConceptScore W2337632357C2778480876 @default.
• W2337632357 hasConceptScore W2337632357C2781080636 @default.
• W2337632357 hasConceptScore W2337632357C31507581 @default.
• W2337632357 hasConceptScore W2337632357C45510557 @default.
• W2337632357 hasConceptScore W2337632357C55493867 @default.
• W2337632357 hasConceptScore W2337632357C62478195 @default.
• W2337632357 hasConceptScore W2337632357C73834784 @default.
• W2337632357 hasConceptScore W2337632357C75520062 @default.
• W2337632357 hasConceptScore W2337632357C82381507 @default.
• W2337632357 hasConceptScore W2337632357C86803240 @default.
• W2337632357 hasConceptScore W2337632357C95444343 @default.
• W2337632357 hasFunder F4320309014 @default.
• W2337632357 hasFunder F4320321457 @default.
• W2337632357 hasFunder F4320322581 @default.

• next