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• W2337637864 abstract "Context: It is unclear how in utero vitamin D deficiency affects the extraskeletal health of children, despite the known risks for adverse pregnancy/birth outcomes. Objective: This systematic review seeks to assess the effect of in utero vitamin D exposure on childhood allergy and infection outcomes using the PRISMA guidelines. Data Sources: MEDLINE, Cochrane Library, and Web of Science databases were searched. Study Selection: Literature published through April 2015 was searched for studies reporting on the association between maternal pregnancy or cord blood vitamin D status and childhood allergy and infection. Data Extraction: Of 4175 articles identified, 43 studies met the inclusion criteria. They examined a wide variety of outcomes, using many different vitamin D cutoff values in their analyses. Data Synthesis: For most outcomes, results were inconsistent, although there appeared to be a protective effect between higher in utero vitamin D status and childhood lower respiratory tract infection (5 of 10 studies). Conclusions: More research is needed on childhood allergy and infection outcomes, and future studies should standardize outcome reporting, especially with regard to cutoff values for vitamin D concentrations. Evidence of a protective association between in utero vitamin D exposure and lower respiratory tract infection was found, while the other outcomes were either understudied or showed inconsistent results. PROSPERO registration no. CRD42013006156." @default.
• W2337637864 created "2016-06-24" @default.
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• W2337637864 date "2016-04-15" @default.
• W2337637864 modified "2023-10-16" @default.
• W2337637864 title "Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review" @default.
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• W2337637864 doi "https://doi.org/10.1093/nutrit/nuv108" @default.
• W2337637864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4892299" @default.
• W2337637864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27083486" @default.
• W2337637864 hasPublicationYear "2016" @default.
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