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- W2337643905 abstract "目的探讨疏风解毒胶囊对D-氨基半乳糖/脂多糖致大鼠急性肝损伤的保护作用及其机制。方法 SD大鼠80只,随机分为对照组、模型组、疏风解毒胶囊组、地塞米松组,每组20只。对照组大鼠ip生理盐水0.5 mL,其他各组ip D-氨基半乳糖（D-Ga1N）700 mg/kg和脂多糖（LPS）10μg/kg制备急性肝损伤模型。地塞米松组每天ip地塞米松5 mg/kg、疏风解毒胶囊组每天ig疏风解毒胶囊100 mg/kg,每天1次,连续给药7 d。取各组大鼠肝组织进行HE染色观察病理学变化;酶联免疫吸附法（ELISA）检测血清相关指标：丙氨酸氨基转移酶（ALT）及天冬氨酸氨基转氨酶（AST）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、鸟氨酸氨基甲酰转移酶（OCT）、高迁移率族蛋白B-1（HMGB-1）、谷胱甘肽转移酶（GST）水平。结果与模型组比较,疏风解毒胶囊组大鼠肝组织的病变程度较轻,大鼠血清ALT、AST、IL-1B、TNF-α、OCT、HMGB-1及GST水平明显下降（P〈0.05）,疏风解毒胶囊组与地塞米松组比较,各项指标差异不显著（P〉0.05）。结论疏风解毒胶囊可通过降低IL-1β及TNF-α水平抑制D-Ga1N/LPS诱导大鼠急性肝脏炎症反应,起到减轻D-GalN/LPS导致的急性肝损伤作用。" @default.
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- W2337643905 date "2015-05-06" @default.
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- W2337643905 title "疏风解毒胶囊对D-氨基半乳糖/脂多糖诱导大鼠急性肝损伤保护作用" @default.
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