Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337646770> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2337646770 endingPage "C1107" @default.
- W2337646770 startingPage "C1100" @default.
- W2337646770 abstract "Human platelets can be stimulated by recombinant human fifth component of complement (rhC5a) in the presence of human neutrophils. After challenge with N-formyl-Met-Leu-Phe or rhC5a, concentrated neutrophils release cathepsin G into the supernatant. The concentrations of cathepsin G recovered by titration of the enzymatic activity correlate with the capability of these supernatants to induce platelet stimulation as measured by serotonin release. Cathepsin G purified from neutrophil granules triggered platelet aggregation and serotonin release independent of arachidonic acid metabolites and platelet-activating factor formation. A concentration of 100 nM of cathepsin G, which was reached in the surrounding space of activated neutrophils, induced a 50% platelet stimulation. Three distinct antiproteinases were tested against cathepsin G-induced platelet activation. Z-Gly-Leu-Phe-CH2Cl, a specific inhibitor of cathepsin G enzymatic activity, proved to be nonspecific in our biological system. By contrast, alpha 1-antichymotrypsin and alpha 1-antitrypsin displayed specific activities. The physiological specific inhibitor of cathepsin G, alpha 1-antichymotrypsin, was the most potent and was used in the rhC5a-induced neutrophils-mediated platelet activation. A complete inhibition was achieved, showing that release of cathepsin G from neutrophils accounts for platelet activation. Such a chain of events involving C5a, neutrophils, cathepsin G, and platelets may be of relevance in certain inflammatory states, particularly the adult respiratory distress syndrome." @default.
- W2337646770 created "2016-06-24" @default.
- W2337646770 creator A5019291198 @default.
- W2337646770 creator A5034205824 @default.
- W2337646770 creator A5043100331 @default.
- W2337646770 creator A5066686177 @default.
- W2337646770 creator A5069665044 @default.
- W2337646770 creator A5088465065 @default.
- W2337646770 date "1990-06-01" @default.
- W2337646770 modified "2023-09-27" @default.
- W2337646770 title "Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G" @default.
- W2337646770 cites W1007663042 @default.
- W2337646770 cites W1173824465 @default.
- W2337646770 cites W145388861 @default.
- W2337646770 cites W1563535758 @default.
- W2337646770 cites W1983057626 @default.
- W2337646770 cites W1992030944 @default.
- W2337646770 cites W2012337787 @default.
- W2337646770 cites W2037082246 @default.
- W2337646770 cites W2064050916 @default.
- W2337646770 cites W2069718808 @default.
- W2337646770 cites W2072517507 @default.
- W2337646770 cites W2109272101 @default.
- W2337646770 cites W2157955666 @default.
- W2337646770 cites W2342357083 @default.
- W2337646770 cites W2411164904 @default.
- W2337646770 doi "https://doi.org/10.1152/ajpcell.1990.258.6.c1100" @default.
- W2337646770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2360620" @default.
- W2337646770 hasPublicationYear "1990" @default.
- W2337646770 type Work @default.
- W2337646770 sameAs 2337646770 @default.
- W2337646770 citedByCount "77" @default.
- W2337646770 countsByYear W23376467702013 @default.
- W2337646770 countsByYear W23376467702014 @default.
- W2337646770 countsByYear W23376467702015 @default.
- W2337646770 countsByYear W23376467702017 @default.
- W2337646770 countsByYear W23376467702018 @default.
- W2337646770 countsByYear W23376467702019 @default.
- W2337646770 countsByYear W23376467702023 @default.
- W2337646770 crossrefType "journal-article" @default.
- W2337646770 hasAuthorship W2337646770A5019291198 @default.
- W2337646770 hasAuthorship W2337646770A5034205824 @default.
- W2337646770 hasAuthorship W2337646770A5043100331 @default.
- W2337646770 hasAuthorship W2337646770A5066686177 @default.
- W2337646770 hasAuthorship W2337646770A5069665044 @default.
- W2337646770 hasAuthorship W2337646770A5088465065 @default.
- W2337646770 hasConcept C134018914 @default.
- W2337646770 hasConcept C145734084 @default.
- W2337646770 hasConcept C153911025 @default.
- W2337646770 hasConcept C167844969 @default.
- W2337646770 hasConcept C181199279 @default.
- W2337646770 hasConcept C185592680 @default.
- W2337646770 hasConcept C203014093 @default.
- W2337646770 hasConcept C24998067 @default.
- W2337646770 hasConcept C2777132095 @default.
- W2337646770 hasConcept C2781044401 @default.
- W2337646770 hasConcept C3018697912 @default.
- W2337646770 hasConcept C55493867 @default.
- W2337646770 hasConcept C86803240 @default.
- W2337646770 hasConcept C89560881 @default.
- W2337646770 hasConceptScore W2337646770C134018914 @default.
- W2337646770 hasConceptScore W2337646770C145734084 @default.
- W2337646770 hasConceptScore W2337646770C153911025 @default.
- W2337646770 hasConceptScore W2337646770C167844969 @default.
- W2337646770 hasConceptScore W2337646770C181199279 @default.
- W2337646770 hasConceptScore W2337646770C185592680 @default.
- W2337646770 hasConceptScore W2337646770C203014093 @default.
- W2337646770 hasConceptScore W2337646770C24998067 @default.
- W2337646770 hasConceptScore W2337646770C2777132095 @default.
- W2337646770 hasConceptScore W2337646770C2781044401 @default.
- W2337646770 hasConceptScore W2337646770C3018697912 @default.
- W2337646770 hasConceptScore W2337646770C55493867 @default.
- W2337646770 hasConceptScore W2337646770C86803240 @default.
- W2337646770 hasConceptScore W2337646770C89560881 @default.
- W2337646770 hasIssue "6" @default.
- W2337646770 hasLocation W23376467701 @default.
- W2337646770 hasLocation W23376467702 @default.
- W2337646770 hasOpenAccess W2337646770 @default.
- W2337646770 hasPrimaryLocation W23376467701 @default.
- W2337646770 hasRelatedWork W1937954306 @default.
- W2337646770 hasRelatedWork W1957872489 @default.
- W2337646770 hasRelatedWork W1977122209 @default.
- W2337646770 hasRelatedWork W2004754196 @default.
- W2337646770 hasRelatedWork W2009386218 @default.
- W2337646770 hasRelatedWork W2137522692 @default.
- W2337646770 hasRelatedWork W2153320404 @default.
- W2337646770 hasRelatedWork W2337646770 @default.
- W2337646770 hasRelatedWork W2951176632 @default.
- W2337646770 hasRelatedWork W974424291 @default.
- W2337646770 hasVolume "258" @default.
- W2337646770 isParatext "false" @default.
- W2337646770 isRetracted "false" @default.
- W2337646770 magId "2337646770" @default.
- W2337646770 workType "article" @default.