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- W2337656162 abstract "Nearly one-third of deaths in the United States are caused by cardiovascular disease (CVD) each year. In the past, CVD was thought to mainly affect men, leading to the exclusion of women and female animals from clinical studies and preclinical research. In light of sexual dimorphisms in CVD, a need exists to examine baseline cardiac differences in humans and the animals used to model CVD. In humans, sex differences are apparent at every level of cardiovascular physiology from action potential duration and mitochondrial energetics to cardiac myocyte and whole-heart contractile function. Biological sex is an important modifier of the development of CVD with younger women generally being protected, but this cardioprotection is lost later in life, suggesting a role for estrogen. Although endogenous estrogen is most likely a mediator of the observed functional differences in both health and disease, the signaling mechanisms involved are complex and are not yet fully understood. To investigate how sex modulates CVD development, animal models are essential tools and should be useful in the development of therapeutics. This review will focus on describing the cardiovascular sexual dimorphisms that exist both physiologically and in common animal models of CVD." @default.
- W2337656162 created "2016-06-24" @default.
- W2337656162 creator A5031118709 @default.
- W2337656162 creator A5081623369 @default.
- W2337656162 creator A5085377296 @default.
- W2337656162 creator A5086771114 @default.
- W2337656162 date "2016-04-15" @default.
- W2337656162 modified "2023-10-15" @default.
- W2337656162 title "The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease" @default.
- W2337656162 cites W132144188 @default.
- W2337656162 cites W1539195752 @default.
- W2337656162 cites W1553914798 @default.
- W2337656162 cites W1607047529 @default.
- W2337656162 cites W1643375850 @default.
- W2337656162 cites W164902024 @default.
- W2337656162 cites W1656644300 @default.
- W2337656162 cites W1895665623 @default.
- W2337656162 cites W1965080988 @default.
- W2337656162 cites W1965377645 @default.
- W2337656162 cites W1965643447 @default.
- W2337656162 cites W1966162027 @default.
- W2337656162 cites W1970337001 @default.
- W2337656162 cites W1972002599 @default.
- W2337656162 cites W1974604615 @default.
- W2337656162 cites W1976301551 @default.
- W2337656162 cites W1979334778 @default.
- W2337656162 cites W1980074678 @default.
- W2337656162 cites W1981256690 @default.
- W2337656162 cites W1983692570 @default.
- W2337656162 cites W1984021823 @default.
- W2337656162 cites W1987676736 @default.
- W2337656162 cites W1990374532 @default.
- W2337656162 cites W1992467460 @default.
- W2337656162 cites W1992872115 @default.
- W2337656162 cites W1993010382 @default.
- W2337656162 cites W1993113568 @default.
- W2337656162 cites W1993286003 @default.
- W2337656162 cites W1993702845 @default.
- W2337656162 cites W1993861129 @default.
- W2337656162 cites W1995918328 @default.
- W2337656162 cites W1996430165 @default.
- W2337656162 cites W1997785875 @default.
- W2337656162 cites W1999648569 @default.
- W2337656162 cites W2000165149 @default.
- W2337656162 cites W2000857746 @default.
- W2337656162 cites W2001991332 @default.
- W2337656162 cites W2003444175 @default.
- W2337656162 cites W2006862162 @default.
- W2337656162 cites W2006973263 @default.
- W2337656162 cites W2008592262 @default.
- W2337656162 cites W2012740498 @default.
- W2337656162 cites W2012874416 @default.
- W2337656162 cites W2013406531 @default.
- W2337656162 cites W2013687955 @default.
- W2337656162 cites W2016254275 @default.
- W2337656162 cites W2016789545 @default.
- W2337656162 cites W2016841050 @default.
- W2337656162 cites W2022324964 @default.
- W2337656162 cites W2022780560 @default.
- W2337656162 cites W2025433084 @default.
- W2337656162 cites W2026171294 @default.
- W2337656162 cites W2027178882 @default.
- W2337656162 cites W2027431314 @default.
- W2337656162 cites W2029667117 @default.
- W2337656162 cites W2032151252 @default.
- W2337656162 cites W2032582743 @default.
- W2337656162 cites W2036133589 @default.
- W2337656162 cites W2036272929 @default.
- W2337656162 cites W2038838876 @default.
- W2337656162 cites W2038944991 @default.
- W2337656162 cites W2039102573 @default.
- W2337656162 cites W2039577288 @default.
- W2337656162 cites W2040002009 @default.
- W2337656162 cites W2044496493 @default.
- W2337656162 cites W2045596701 @default.
- W2337656162 cites W2046609059 @default.
- W2337656162 cites W2049542909 @default.
- W2337656162 cites W204998232 @default.
- W2337656162 cites W2050824263 @default.
- W2337656162 cites W2057826553 @default.
- W2337656162 cites W2058878434 @default.
- W2337656162 cites W2059770288 @default.
- W2337656162 cites W2060174897 @default.
- W2337656162 cites W2061277131 @default.
- W2337656162 cites W2062161475 @default.
- W2337656162 cites W2068259322 @default.
- W2337656162 cites W2068313326 @default.
- W2337656162 cites W2068705524 @default.
- W2337656162 cites W2069051394 @default.
- W2337656162 cites W2069088060 @default.
- W2337656162 cites W2076122182 @default.
- W2337656162 cites W2079746034 @default.
- W2337656162 cites W2080150476 @default.
- W2337656162 cites W2080632495 @default.
- W2337656162 cites W2082776465 @default.
- W2337656162 cites W2082937555 @default.
- W2337656162 cites W2082978666 @default.
- W2337656162 cites W2084374042 @default.