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- W2337658135 abstract "Chitosan Oligosaccharide (COS) nanoparticles prepared by ionotropic gelation method using sodium tri-polyphosphate (Na-TPP) coated with Hyaluronic acid (HA). The coating confers biological advantage to the nanoparticles in terms improved circulation time in the plasma and targeting ability. This nanoparticulate system has potential application in targeted nucleic acid delivery as they can be tuned to possess overall cationic properties for binding anionic nucleic acids. In the present investigation, we studied the effect of COS of varying molecular weights on the formation COS-TPP nanoparticles coated with HA. Amongst them, COS with higher molecular weight resulted in formation of stable nanoparticles, along with TPP and HA. We also investigated the influence of molecular weight of COS on their physico-chemical properties, in particular, the ability to form nanoparticles with a narrow-size distribution. Furthermore, computational studies were conducted to understand molecular mechanism, which revealed that protonation modulates the behaviour of COS during formation of stable nanoparticles." @default.
- W2337658135 created "2016-06-24" @default.
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- W2337658135 date "2016-06-01" @default.
- W2337658135 modified "2023-09-27" @default.
- W2337658135 title "Investigating behaviour of polymers in nanoparticles of Chitosan Oligosaccharides coated with Hyaluronic Acid" @default.
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- W2337658135 doi "https://doi.org/10.1016/j.polymer.2016.04.027" @default.
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