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- W2337665624 abstract "Thomsen–Friedenreich (TF) antigen is an important tumor-associated carbohydrate antigen. Its low immunogenicity, however, limits its application in the development of anticancer vaccines. To solve this problem, several N-acyl-modified TF derivatives were synthesized and conjugated with carrier protein CRM197 (a mutated diphtheria toxoid cross-reactive material). The immunological results in BALB/c mice demonstrated that these modified TF antigen conjugates could stimulate the production of higher titers of IgG antibodies that cross-reacted with native TF antigen. These glycoconjugates showed strong lymphocyte proliferative response, suggesting that they can induce cellular immunity. Furthermore, the elicited antisera reacted strongly with TF-positive tumor cells (4T1). In particular, the N-monofluoroacetyl-modified TF conjugate 4-CRM197 showed the strongest complement-dependent cytotoxicity effect against 4T1 cells, implying the potential of this glycoconjugate as an anticancer vaccine." @default.
- W2337665624 created "2016-06-24" @default.
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- W2337665624 date "2016-04-14" @default.
- W2337665624 modified "2023-10-17" @default.
- W2337665624 title "Synthesis and Evaluation of Glycoconjugates Comprising<i>N</i>-Acyl-Modified Thomsen-Friedenreich Antigens as Anticancer Vaccines" @default.
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- W2337665624 doi "https://doi.org/10.1002/cmdc.201600094" @default.
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