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• W2337667038 abstract "Objective: Investigate effects of a six minute walk (6MWT) on gait characteristics in PwMS and contrast a healthy control population.Background: Multiple Sclerosis (MS) can impact ambulation in people with MS (PwMS). Analysis of disease impact typically includes EDSS and 25 foot timed walk (T25W) neither of which captures walking changes with prolonged ambulation or exertion. Patient reported outcomes (PRO) provide information about disease impact or change which may not correlate with EDSS or MRI. Identifying comprehensive objective metrics evaluating PRO are required to understand this discrepancy and accurately assess disease impact/progression. Objective analytics might effectively determine treatment needs.Design/Methods: 24 PwMS (EDSS 0-6) and 24 age, gender, height and weight matched normal. Velocity, stride length and double support time were measured with an instrumented mat (GAITRite). Two trials (test-retest) at a self-selected walking speed (preferred walking speed, PWS) were performed and averaged. Modified 6MWT was utilized to simulate motor fatigue with gait parameters measured prior to and following 6 minutes walking. Within and between group gait characteristic changes following the 6MWT were analyzed with dependent and independent t-tests, respectively.Results: GAITRite system demonstrated test-retest reliability and reproducibility for Velocity (r=.955; r2=.912; t=2.131), Stride length (r=.966; r2=.933; t=1.457), Double support time (r=.961; r2=.924; t=1.186). Following 6MWT PwMS demonstrated decreased gait velocity, stride length and increased double support time (all P<.01). Comparison of pre-to-posttest change scores demonstrated decreased velocity and stride length in PwMS (P<0.01 for each) compared to controls, with PwMS slowing 14[percnt] more than their healthy peers post-test gait analysis.Conclusions: PwMS demonstrate greater impairment in gait velocity and stride length following 6MWT than controls. This impact is captured neither by EDSS or T25W. Objective digital gait analysis of PWS in PwMS captures disease impact beyond the EDSS or T25W and might impact analysis of disease burden or change. Disclosure: Dr. Gudesblatt has received personal compensation for activities with Biogen, Teva Neuroscience, Medtronic, Acorda, and Genzyme as a consultant, and from Novartis as part of the Advisory Board. Dr. Burke has nothing to disclose. Dr. Wissemann has nothing to disclose. Dr. Zarif has received personal compensation for activities with Biogen Idec, Teva Neuroscience, Novartis and Questcor Pharmaceuticals. Dr. Bumstead has received personal compensation for activities with Biogen Idec and Teva as a consultant. Dr. Fafard has nothing to disclose. Dr. Thotam has nothing to disclose. Dr. Magel has nothing to disclose. Dr. Buhse has received personal compensation for activities with Biogen Idec, Teva Neuroscience, Bayer Pharmaceuticals, and Questcor as a consultant. Dr. Muratori has nothing to disclose." @default.
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• W2337667038 date "2016-04-05" @default.
• W2337667038 modified "2023-09-26" @default.
• W2337667038 title "Multiple Sclerosis, EDSS and Walking: Computerized Objective Gait Analysis of the Impact of a 6-Minute Timed Walk on Selected Gait Characteristics in People with Multiple Sclerosis - Putting Long Legs on a Walking Scale (P2.153)" @default.
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