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• W2337668086 abstract "Recent high-throughput studies revealed recurrent RUNX1 mutations in breast cancer, specifically in oestrogen receptor-positive (ER(+)) tumours. However, mechanisms underlying the implied RUNX1-mediated tumour suppression remain elusive. Here, by depleting mammary epithelial cells of RUNX1 in vivo and in vitro, we demonstrate combinatorial regulation of AXIN1 by RUNX1 and oestrogen. RUNX1 and ER occupy adjacent elements in AXIN1's second intron, and RUNX1 antagonizes oestrogen-mediated AXIN1 suppression. Accordingly, RNA-seq and immunohistochemical analyses demonstrate an ER-dependent correlation between RUNX1 and AXIN1 in tumour biopsies. RUNX1 loss in ER(+) mammary epithelial cells increases β-catenin, deregulates mitosis and stimulates cell proliferation and expression of stem cell markers. However, it does not stimulate LEF/TCF, c-Myc or CCND1, and it does not accelerate G1/S cell cycle phase transition. Finally, RUNX1 loss-mediated deregulation of β-catenin and mitosis is ameliorated by AXIN1 stabilization in vitro, highlighting AXIN1 as a potential target for the management of ER(+) breast cancer." @default.
• W2337668086 created "2016-06-24" @default.
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• W2337668086 date "2016-02-26" @default.
• W2337668086 modified "2023-10-18" @default.
• W2337668086 title "RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer" @default.
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• W2337668086 doi "https://doi.org/10.1038/ncomms10751" @default.
• W2337668086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773428" @default.
• W2337668086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26916619" @default.
• W2337668086 hasPublicationYear "2016" @default.
• W2337668086 type Work @default.

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