FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337679736> ?p ?o ?g. }

• W2337679736 endingPage "81" @default.
• W2337679736 startingPage "72" @default.
• W2337679736 abstract "1 , Miriam Cupic 1 , Ines Potocnjak 2 , Matias Trbusic Abstract Due to the high morbidity and mortality rates, severe sepsis and septic shock, present a major global public health problem. The treatment and management of severe sepsis and septic shock is based on a set of international guidelines called the Surviving sepsis campaign (SSC). SSC guidelines suggest the use of hydrocortisone at a dose of 200 mg IV in adult patients with septic shock refractory to fluid resuscitation and vasopressors. During the last century, the importance of cortisol as an essential hormone at times of stress, such as septic shock, has been recognized. Therefore, the therapeutic use of synthetic glucocorticoids has been the subject of many studies during the last few decades but their results are not consistent. Two of the largest studies (CORTICUS and French study) showed different effects of synthetic glucocorticoids on mortality rates, but they both showed a significantly shorter duration of septic shock. There is an ongoing large, multicenter, double-blind, randomized study (ADRENAL study) and its primary goal is to assess the impact of hydrocortisone therapy on 90-day survival rate. It is expected that the results of this study might provide answers to the questions raised by previously conducted studies. This review will summarize the pathophysiology of sepsis and septic shock and the role of cortisol in its development, and will highlight the most important clinical studies pertaining to synthetic glucocorticoid administration in sepsis and septic shock." @default.
• W2337679736 created "2016-06-24" @default.
• W2337679736 creator A5012709642 @default.
• W2337679736 creator A5025672030 @default.
• W2337679736 creator A5051283801 @default.
• W2337679736 creator A5063665396 @default.
• W2337679736 creator A5087386460 @default.
• W2337679736 date "2016-03-15" @default.
• W2337679736 modified "2023-09-26" @default.
• W2337679736 title "The effectiveness of synthetic glucocorticoids on the disease course, treatment, and outcome of severe sepsis and septic shock" @default.
• W2337679736 cites W135365591 @default.
• W2337679736 cites W1581427837 @default.
• W2337679736 cites W166426311 @default.
• W2337679736 cites W1674596953 @default.
• W2337679736 cites W1949289403 @default.
• W2337679736 cites W1965740452 @default.
• W2337679736 cites W1977905350 @default.
• W2337679736 cites W1981243375 @default.
• W2337679736 cites W1983840348 @default.
• W2337679736 cites W1992334957 @default.
• W2337679736 cites W2000421482 @default.
• W2337679736 cites W2001102650 @default.
• W2337679736 cites W2002730524 @default.
• W2337679736 cites W2004061569 @default.
• W2337679736 cites W2015205968 @default.
• W2337679736 cites W2019153103 @default.
• W2337679736 cites W2025514580 @default.
• W2337679736 cites W2025679899 @default.
• W2337679736 cites W2025905046 @default.
• W2337679736 cites W2027832337 @default.
• W2337679736 cites W2027977470 @default.
• W2337679736 cites W2030097812 @default.
• W2337679736 cites W2032772673 @default.
• W2337679736 cites W2042268246 @default.
• W2337679736 cites W2049078194 @default.
• W2337679736 cites W2052375478 @default.
• W2337679736 cites W2059295104 @default.
• W2337679736 cites W2061441008 @default.
• W2337679736 cites W2062209205 @default.
• W2337679736 cites W2065755424 @default.
• W2337679736 cites W2067535945 @default.
• W2337679736 cites W2070743921 @default.
• W2337679736 cites W2072393428 @default.
• W2337679736 cites W2073446553 @default.
• W2337679736 cites W2076507733 @default.
• W2337679736 cites W2083380272 @default.
• W2337679736 cites W2084683053 @default.
• W2337679736 cites W2088781708 @default.
• W2337679736 cites W2100018795 @default.
• W2337679736 cites W2112989757 @default.
• W2337679736 cites W2113535256 @default.
• W2337679736 cites W2115913948 @default.
• W2337679736 cites W2122453141 @default.
• W2337679736 cites W2125017989 @default.
• W2337679736 cites W2139392826 @default.
• W2337679736 cites W2143734001 @default.
• W2337679736 cites W2158699273 @default.
• W2337679736 cites W2160691650 @default.
• W2337679736 cites W2234698408 @default.
• W2337679736 cites W2314101063 @default.
• W2337679736 cites W2336871225 @default.
• W2337679736 cites W2414948593 @default.
• W2337679736 cites W2442246762 @default.
• W2337679736 cites W2550507245 @default.
• W2337679736 cites W2965969587 @default.
• W2337679736 cites W3023757607 @default.
• W2337679736 doi "https://doi.org/10.21040/eom/2016.2.8" @default.
• W2337679736 hasPublicationYear "2016" @default.
• W2337679736 type Work @default.
• W2337679736 sameAs 2337679736 @default.
• W2337679736 citedByCount "0" @default.
• W2337679736 crossrefType "journal-article" @default.
• W2337679736 hasAuthorship W2337679736A5012709642 @default.
• W2337679736 hasAuthorship W2337679736A5025672030 @default.
• W2337679736 hasAuthorship W2337679736A5051283801 @default.
• W2337679736 hasAuthorship W2337679736A5063665396 @default.
• W2337679736 hasAuthorship W2337679736A5087386460 @default.
• W2337679736 hasBestOaLocation W23376797361 @default.
• W2337679736 hasConcept C126322002 @default.
• W2337679736 hasConcept C144237770 @default.
• W2337679736 hasConcept C148220186 @default.
• W2337679736 hasConcept C177713679 @default.
• W2337679736 hasConcept C2777628635 @default.
• W2337679736 hasConcept C2778384902 @default.
• W2337679736 hasConcept C2779134260 @default.
• W2337679736 hasConcept C2781300812 @default.
• W2337679736 hasConcept C2994086866 @default.
• W2337679736 hasConcept C33923547 @default.
• W2337679736 hasConcept C71924100 @default.
• W2337679736 hasConceptScore W2337679736C126322002 @default.
• W2337679736 hasConceptScore W2337679736C144237770 @default.
• W2337679736 hasConceptScore W2337679736C148220186 @default.
• W2337679736 hasConceptScore W2337679736C177713679 @default.
• W2337679736 hasConceptScore W2337679736C2777628635 @default.
• W2337679736 hasConceptScore W2337679736C2778384902 @default.
• W2337679736 hasConceptScore W2337679736C2779134260 @default.
• W2337679736 hasConceptScore W2337679736C2781300812 @default.
• W2337679736 hasConceptScore W2337679736C2994086866 @default.

• next