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- W233769138 abstract "This chapter describes the EEG effects of clozapine. In the past two decades, a theory of the association of EEG and behavior and a methodology designed to predict the useful role of new psychoactive drugs have been developed. The theory states that psychoactive drugs systematically affect brain functions such that distinctive EEG patterns are elicited that are directly related to the behavioral effects in man. Drugs with similar EEG patterns have similar behavioral effects, and drugs that fail to elicit EEG effects fail to have systematic behavioral effects. The theory was first challenged by pharmacologic studies with anticholinergic drugs in which surface EEG electrodes showed slow frequency high-voltage patterns characteristic of sleep while the studied animal was restless, exhibited running movements, and vocalized. An increase in EEG slow waves and in fast frequencies, a decrease in alpha amplitudes, an increase in variability of frequencies, and a decrease in rhythmicity is associated with heightened mood, increased psychomotor activity, and decreased vigilance and alertness. These effects are seen with the tricyclic and tetracyclic thymoleptic antidepressant drugs." @default.
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- W233769138 date "1979-01-01" @default.
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- W233769138 title "EEG Effects of Clozapine: Assocation or Dissocation of EEG and Behavior?" @default.
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- W233769138 doi "https://doi.org/10.1016/b978-0-08-023089-4.50042-9" @default.
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