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• W2337696553 abstract "The principals on which clinical pathology is based in human and veterinary medicine are similar and are based on the detection of deviations from recognized and predetermined sets of analytes and cells in the blood, urine, cerebrospinal and other body fluids. They include chemical-biochemical, physical hematological, microscopic and other parameters, relating to diseases, metabolic disorders, nutritional imbalances and deficiencies, environmental conditions, stress and more, guiding the clinicians, practitioners and farmers for treatments, optimization of nutrition and management practices. All these are based on sets of characteristic clinical pathology profiles determined and defined as normal. One of the big problems facing the clinical chemist and clinician is the definition of the so-called normal profile. Since by definition the decision of abnormal value is depending on it. Since genetics, physiology, nutrition and environmental conditions are influencing the clinical pathology profiles, it is necessary to establish these normal reference values, for each animal species, under defined environmental and nutritional conditions according to age, sex and physiological conditions. While for human and some animal species such as dogs, cats and large farm animals, these profiles are well established, for more exotic animals like the camelides, the picture is incomplete, confusing and in disagreement within the different reported data. Overviewing the literature on camelides clinical pathology reveals the following: a) the available data is inconsistent, having a wide range of values, which are in disagreement with each other. Values reported as normal reference were obtained on relatively small and undefined groups of animals with no reference to age, sex nutritional regime and environmental and management conditions ; b) the range of analytes studied is narrow and does not include many analytes, which were studied with other animal groups ; c) there are significant differences in the values of many parameters, compared to other animal species within the camelides family, as well as other species. This could be a consequent of different genetics, physiology and environmental conditions, stressing the need to establish reference values to each group of animals. An overview on the principles of clinical pathology, normal and pathological profiles will be presented. Examples of the variations among the reported values in the literature and the possible relation to difference in methodological procedures will be discussed and the possible relationship between the different profiles and difference in genetics and environmental conditions. New data on the proteins and isoenzyme profiles in camelides separated and identified by electrophoresis. Further more, the utilization of dry chemistry technology for animal side testing and the computer, as an aid to the clinician in the interpretation of clinical pathology in camelides veterinary medicine will be discussed. Further research is needed to bring camelides clinical pathology to the levels existing in small animals and large farm animals." @default.
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• W2337696553 title "Clinical pathology of Camelides : present and future" @default.
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