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- W2337700139 abstract "Single-voxel proton magnetic resonance spectroscopy (MRS) is a quantitative magnetic resonance (MR) technique for measuring the levels of multiple metabolites from the tissue of interest. MRS brain metabolites that are consistently abnormal in Alzheimer disease (AD) include an elevation in myo-inositol (mI) and a decrease in the neuronal metabolite N -acetylaspartate (NAA). Evidence from longitudinal studies suggests that changes in mI, a surrogate measure for neuroinflammation, and NAA, a measure of compromise in neuronal viability, occur at different stages during the progression of AD. Whereas mI is elevated during the preclinical stages of AD, and continues to be elevated throughout the disease course, decreases in NAA are not generally detected until the diagnosis of mild cognitive impairment, and continue to decline as the disease progresses." @default.
- W2337700139 created "2016-06-24" @default.
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- W2337700139 date "2016-04-15" @default.
- W2337700139 modified "2023-10-18" @default.
- W2337700139 title "MR spectroscopy,APOEgenotype, and evolving β-amyloid pathology" @default.
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- W2337700139 doi "https://doi.org/10.1212/wnl.0000000000002680" @default.
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