FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337740292> ?p ?o ?g. }

• W2337740292 abstract "AimNatural killer (NK) cells play an important role in immune surveillance against viral diseases and cancer. Probiotics, live bacteria beneficial to human health, and some bacterial metabolic products are reported to augment NK cell activity and possibly result in the prevention of tumor development. The aim of this study was to investigate the effect of an extract of metabolic products of Bacillus subtilis AK (EMBSAK), a selected clone of Bacillus subtilis natto, on NK cell activity in human volunteers and mice.MethodsIn the human study, healthy volunteers ingested an EMBSAK-containing commercially available product, SARABAGAN, for 7 days. In the mice study, BALB/c wild-type (WT), interferon (IFN)-γ-deficient ( IFN-γ−/−) and RAG 2-deficient ( RAG −/− ) mice were given oral SARABAGAN 80 mg/kg/day for 7 days. Cytotoxic activity and NK cell number were then examined on 51Cr release assay and flow cytometry, respectively.ResultsOral EMBSAK frequently increased NK cell cytotoxicity, but not NK cell population, in human volunteers in a dose-dependent manner. Moreover, oral EMBSAK augmented NK cell cytotoxicity, but not NK cell number and population, in WT and RAG 2-deficient, but not IFN-γ-deficient, mice. This suggests that supplemental intake of EMBSAK enhances NK cell cytotoxic activity, but not cell number, depending on IFN-γ but not on acquired immune cells.ConclusionEMBSAK may be useful to prevent infectious and malignant disease via activation of NK cell cytotoxicity." @default.
• W2337740292 created "2016-06-24" @default.
• W2337740292 creator A5067307105 @default.
• W2337740292 creator A5074513079 @default.
• W2337740292 creator A5088986458 @default.
• W2337740292 date "2016-10-01" @default.
• W2337740292 modified "2023-09-24" @default.
• W2337740292 title "Extract of metabolic products of Bacillus subtilis AK augments natural killer cell cytotoxic activity" @default.
• W2337740292 cites W1277933029 @default.
• W2337740292 cites W1522937979 @default.
• W2337740292 cites W1556867369 @default.
• W2337740292 cites W1905558879 @default.
• W2337740292 cites W1963769630 @default.
• W2337740292 cites W1968508664 @default.
• W2337740292 cites W1969608079 @default.
• W2337740292 cites W1996517462 @default.
• W2337740292 cites W1999327751 @default.
• W2337740292 cites W2000673669 @default.
• W2337740292 cites W2008221423 @default.
• W2337740292 cites W2016840712 @default.
• W2337740292 cites W2019813857 @default.
• W2337740292 cites W2040840388 @default.
• W2337740292 cites W2051659824 @default.
• W2337740292 cites W2058338960 @default.
• W2337740292 cites W2061453528 @default.
• W2337740292 cites W2088910907 @default.
• W2337740292 cites W2100704940 @default.
• W2337740292 cites W2101363646 @default.
• W2337740292 cites W2108473659 @default.
• W2337740292 cites W2120291810 @default.
• W2337740292 cites W2125995862 @default.
• W2337740292 cites W2130420795 @default.
• W2337740292 cites W2140245905 @default.
• W2337740292 cites W2157269038 @default.
• W2337740292 cites W2161888789 @default.
• W2337740292 cites W4250647025 @default.
• W2337740292 doi "https://doi.org/10.1002/tkm2.1046" @default.
• W2337740292 hasPublicationYear "2016" @default.
• W2337740292 type Work @default.
• W2337740292 sameAs 2337740292 @default.
• W2337740292 citedByCount "2" @default.
• W2337740292 countsByYear W23377402922018 @default.
• W2337740292 countsByYear W23377402922019 @default.
• W2337740292 crossrefType "journal-article" @default.
• W2337740292 hasAuthorship W2337740292A5067307105 @default.
• W2337740292 hasAuthorship W2337740292A5074513079 @default.
• W2337740292 hasAuthorship W2337740292A5088986458 @default.
• W2337740292 hasBestOaLocation W23377402921 @default.
• W2337740292 hasConcept C109316439 @default.
• W2337740292 hasConcept C1491633281 @default.
• W2337740292 hasConcept C154317977 @default.
• W2337740292 hasConcept C202751555 @default.
• W2337740292 hasConcept C203014093 @default.
• W2337740292 hasConcept C2777272437 @default.
• W2337740292 hasConcept C2778102761 @default.
• W2337740292 hasConcept C2908647359 @default.
• W2337740292 hasConcept C523546767 @default.
• W2337740292 hasConcept C54355233 @default.
• W2337740292 hasConcept C553184892 @default.
• W2337740292 hasConcept C55493867 @default.
• W2337740292 hasConcept C71924100 @default.
• W2337740292 hasConcept C86803240 @default.
• W2337740292 hasConcept C8891405 @default.
• W2337740292 hasConcept C89423630 @default.
• W2337740292 hasConcept C99454951 @default.
• W2337740292 hasConceptScore W2337740292C109316439 @default.
• W2337740292 hasConceptScore W2337740292C1491633281 @default.
• W2337740292 hasConceptScore W2337740292C154317977 @default.
• W2337740292 hasConceptScore W2337740292C202751555 @default.
• W2337740292 hasConceptScore W2337740292C203014093 @default.
• W2337740292 hasConceptScore W2337740292C2777272437 @default.
• W2337740292 hasConceptScore W2337740292C2778102761 @default.
• W2337740292 hasConceptScore W2337740292C2908647359 @default.
• W2337740292 hasConceptScore W2337740292C523546767 @default.
• W2337740292 hasConceptScore W2337740292C54355233 @default.
• W2337740292 hasConceptScore W2337740292C553184892 @default.
• W2337740292 hasConceptScore W2337740292C55493867 @default.
• W2337740292 hasConceptScore W2337740292C71924100 @default.
• W2337740292 hasConceptScore W2337740292C86803240 @default.
• W2337740292 hasConceptScore W2337740292C8891405 @default.
• W2337740292 hasConceptScore W2337740292C89423630 @default.
• W2337740292 hasConceptScore W2337740292C99454951 @default.
• W2337740292 hasFunder F4320311006 @default.
• W2337740292 hasLocation W23377402921 @default.
• W2337740292 hasOpenAccess W2337740292 @default.
• W2337740292 hasPrimaryLocation W23377402921 @default.
• W2337740292 hasRelatedWork W1926360199 @default.
• W2337740292 hasRelatedWork W1938270986 @default.
• W2337740292 hasRelatedWork W1969080495 @default.
• W2337740292 hasRelatedWork W1984675864 @default.
• W2337740292 hasRelatedWork W1991360369 @default.
• W2337740292 hasRelatedWork W1991432849 @default.
• W2337740292 hasRelatedWork W1993319836 @default.
• W2337740292 hasRelatedWork W1994299544 @default.
• W2337740292 hasRelatedWork W1996517462 @default.
• W2337740292 hasRelatedWork W2005755208 @default.
• W2337740292 hasRelatedWork W2017919104 @default.
• W2337740292 hasRelatedWork W2037105294 @default.
• W2337740292 hasRelatedWork W2054156041 @default.
• W2337740292 hasRelatedWork W2075121741 @default.

• next