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• W2337753324 abstract "Biocompatible, biodegradable, and luminescent nano material can be used as an alternative bioimaging agent for early cancer diagnosis, which is crucial to achieve successful treatment. Hydroxyapatite (HAP) nanocyrstals have good biocompatibility and biodegradability, and can be used as an excellent host for luminescent rare earth elements. In this study, based on the energy transfer from Gd3+ to Eu3+, the luminescence enhanced imaging agent of Eu/Gd codoping HAP (HAP:Eu/Gd) nanocrystals are obtained via coprecipitation with plate-like shape and no change in crystal phase composition. The luminescence can be much elevated (up to about 120%) with a nonlinear increase versus Gd doping content, which is due to the energy transfer (6PJ of Gd3+ → 5HJ of Eu3+) under 273 nm and the possible combination effect of the cooperative upconversion and the successive energy transfer under 394 nm, respectively. Results demonstrate that the biocompatible HAP:Eu/Gd nanocrystals can successfully perform cell labeling and in vivo imaging. The intracellular HAP:Eu/Gd nanocrystals display good biodegradability with a cumulative degradation of about 65% after 72 h. This biocompatible, biodegradable, and luminescence enhanced HAP:Eu/Gd nanocrystal has the potential to act as a fluorescent imaging agent in vitro and in vivo." @default.
• W2337753324 created "2016-06-24" @default.
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• W2337753324 date "2016-04-13" @default.
• W2337753324 modified "2023-10-16" @default.
• W2337753324 title "Luminescence Enhanced Eu³⁺/Gd³⁺ Co-Doped Hydroxyapatite Nanocrystals as Imaging Agents In Vitro and In Vivo" @default.
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• W2337753324 doi "https://doi.org/10.1021/acsami.6b01814" @default.
• W2337753324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27043792" @default.
• W2337753324 hasPublicationYear "2016" @default.
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