FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337763018> ?p ?o ?g. }

• W2337763018 abstract "Background The cardiovascular effects of positive airway pressure ( PAP ) therapy in obstructive sleep apnea ( OSA ) patients are not clear because of confounding by comorbid conditions. Methods and Results Prospective interventional study of PAP therapy and withdrawal. Apnea Hypopnea Index ( AHI ; events/hour of sleep) was determined from polysomnography. Central aortic blood pressures ( BPs ), Aortic Augmentation Index ( AAI x), and central ( PWV c‐f ) and peripheral pulse wave ( PWV c‐r ) velocities were determined by applanation tonometry. Echocardiography and brachial artery reactivity testing were performed at baseline, after 4 and 12 weeks of PAP therapy, and 1 week after PAP withdrawal. The 84 participants were mean (SD) 41.1 (7.6) years old and had 39.8 (24.5) AHI events/hour. After 4 weeks post‐ PAP initiation and sustained after 12 weeks, subjects experienced decreases in central systolic BP ( P =0.008), diastolic BP , mean BP , AAI x, and PWV c‐r , and brachial artery dilation (all P <0.001), as well as improvements in left ventricular diastolic function and systemic and pulmonary vascular resistance. In adjusted models, PAP use (hours/night) predicted reductions in diastolic BP (β=−0.65 [SE, 0.32] mm Hg/hour; P =0.045), AAI x (β=−0.53 [0.27] %/hour; P =0.049) and PWV c‐r (β=−0.13 [0.05] m·s −1 /hour; P =0.007), and improved brachial artery flow‐mediated dilation (β=0.31 [0.14] %/hour use; P =0.015). After 1 week of PAP withdrawal, brachial diameter, diastolic BP , mean BP , AAI x, and heart rate increased ( P ≤0.05). Conclusions PAP therapy reduces arterial tone and improves endothelial and diastolic function in young to middle‐aged adults. This positive effect is observed after 4 weeks and depends on hours of use, but reverts quickly with PAP withdrawal. Clinical Trial Registration URL: https://clinicaltrials.gov/ . Unique identifier: NCT 01317329." @default.
• W2337763018 created "2016-06-24" @default.
• W2337763018 creator A5021308656 @default.
• W2337763018 creator A5049632383 @default.
• W2337763018 creator A5055013057 @default.
• W2337763018 creator A5089513294 @default.
• W2337763018 date "2016-04-03" @default.
• W2337763018 modified "2023-10-10" @default.
• W2337763018 title "Treatment of Obstructive Sleep Apnea in Young and Middle‐Aged Adults: Effects of Positive Airway Pressure and Compliance on Arterial Stiffness, Endothelial Function, and Cardiac Hemodynamics" @default.
• W2337763018 cites W138587671 @default.
• W2337763018 cites W1555489744 @default.
• W2337763018 cites W1918196193 @default.
• W2337763018 cites W1967796855 @default.
• W2337763018 cites W1970990770 @default.
• W2337763018 cites W1976726694 @default.
• W2337763018 cites W1985360781 @default.
• W2337763018 cites W1998146567 @default.
• W2337763018 cites W2004079797 @default.
• W2337763018 cites W2011623435 @default.
• W2337763018 cites W2018804515 @default.
• W2337763018 cites W2023606650 @default.
• W2337763018 cites W2026125870 @default.
• W2337763018 cites W2027496497 @default.
• W2337763018 cites W2048238870 @default.
• W2337763018 cites W2054778814 @default.
• W2337763018 cites W2067833505 @default.
• W2337763018 cites W2087616063 @default.
• W2337763018 cites W2100467513 @default.
• W2337763018 cites W2100731116 @default.
• W2337763018 cites W2101099004 @default.
• W2337763018 cites W2106044895 @default.
• W2337763018 cites W2110849186 @default.
• W2337763018 cites W2112943642 @default.
• W2337763018 cites W2117834225 @default.
• W2337763018 cites W2118297767 @default.
• W2337763018 cites W2127261816 @default.
• W2337763018 cites W2128416574 @default.
• W2337763018 cites W2133544352 @default.
• W2337763018 cites W2138209376 @default.
• W2337763018 cites W2144086544 @default.
• W2337763018 cites W2144120465 @default.
• W2337763018 cites W2155704307 @default.
• W2337763018 cites W2157795483 @default.
• W2337763018 cites W2158707863 @default.
• W2337763018 cites W2161355380 @default.
• W2337763018 cites W2165384819 @default.
• W2337763018 cites W2165730407 @default.
• W2337763018 cites W2166761488 @default.
• W2337763018 cites W2170390946 @default.
• W2337763018 cites W2185790535 @default.
• W2337763018 cites W2187630416 @default.
• W2337763018 cites W2335449614 @default.
• W2337763018 cites W3022179669 @default.
• W2337763018 cites W4233235818 @default.
• W2337763018 cites W83571168 @default.
• W2337763018 doi "https://doi.org/10.1161/jaha.115.002930" @default.
• W2337763018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4859282" @default.
• W2337763018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27039928" @default.
• W2337763018 hasPublicationYear "2016" @default.
• W2337763018 type Work @default.
• W2337763018 sameAs 2337763018 @default.
• W2337763018 citedByCount "21" @default.
• W2337763018 countsByYear W23377630182017 @default.
• W2337763018 countsByYear W23377630182018 @default.
• W2337763018 countsByYear W23377630182019 @default.
• W2337763018 countsByYear W23377630182020 @default.
• W2337763018 countsByYear W23377630182021 @default.
• W2337763018 countsByYear W23377630182022 @default.
• W2337763018 countsByYear W23377630182023 @default.
• W2337763018 crossrefType "journal-article" @default.
• W2337763018 hasAuthorship W2337763018A5021308656 @default.
• W2337763018 hasAuthorship W2337763018A5049632383 @default.
• W2337763018 hasAuthorship W2337763018A5055013057 @default.
• W2337763018 hasAuthorship W2337763018A5089513294 @default.
• W2337763018 hasBestOaLocation W23377630181 @default.
• W2337763018 hasConcept C126322002 @default.
• W2337763018 hasConcept C164705383 @default.
• W2337763018 hasConcept C2775850156 @default.
• W2337763018 hasConcept C2775867611 @default.
• W2337763018 hasConcept C2776006263 @default.
• W2337763018 hasConcept C2777604165 @default.
• W2337763018 hasConcept C2778205975 @default.
• W2337763018 hasConcept C2778319312 @default.
• W2337763018 hasConcept C2780168309 @default.
• W2337763018 hasConcept C2781326671 @default.
• W2337763018 hasConcept C57900726 @default.
• W2337763018 hasConcept C58245268 @default.
• W2337763018 hasConcept C71924100 @default.
• W2337763018 hasConcept C84393581 @default.
• W2337763018 hasConceptScore W2337763018C126322002 @default.
• W2337763018 hasConceptScore W2337763018C164705383 @default.
• W2337763018 hasConceptScore W2337763018C2775850156 @default.
• W2337763018 hasConceptScore W2337763018C2775867611 @default.
• W2337763018 hasConceptScore W2337763018C2776006263 @default.
• W2337763018 hasConceptScore W2337763018C2777604165 @default.
• W2337763018 hasConceptScore W2337763018C2778205975 @default.
• W2337763018 hasConceptScore W2337763018C2778319312 @default.
• W2337763018 hasConceptScore W2337763018C2780168309 @default.
• W2337763018 hasConceptScore W2337763018C2781326671 @default.
• W2337763018 hasConceptScore W2337763018C57900726 @default.

• next